CGM Evaluation of Glucose Excursions in Basal Insulin Treated T2DM at Fasting Glucose Target
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This is a trial to determine if patients who are well controlled and on basal insulin are treated with excessive basal dose.
Condition or disease
Type 2 Diabetes
In many clinical trials, basal insulin is titrated to only a fasting glucose goal. The usual final dose is >0.4U/kg. In carefully CGM monitored/titrated studies in both basal insulin alone or in pump-treated T2DM, we have found the basal insulin dose to be <0.3U/kg. This suggests that if guided by a single daily fasting glucose, titration may result in an excessive basal dose. This study will examine that issue.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Subjects will be recruited from the Diabetes Care Center clinic
Type 2 diabetes
Age 18 years and above
Concurrently on +/-thiazolidnedione +/-DDP IV inhibitors +/-metformin +/- glinides and basal insulin analogs
A1C 10% or below
Capable of self monitoring glucose at least 4 x a day
Previously compliant with clinical recommendations
Fasting blood glucose <110mg/dl average for 3 consecutive days
BMI <45 kg/m
Current or expected alternation in insulin sensitivity such as major surgery, infection, renal failure, glucocorticoid treatment, recent serious hypoglycaemic episode
Currently participating in another clinical trial
Using rapid insulin insulin
Pregnancy or nursing or the intention of becoming pregnant or not using adequate birth control