MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder.
This proposal is focused on developing a reliable, valid, and reproducible imaging techniques and statistical methodology for segregation of various forms of Parkinsonism from healthy adults without Parkinsonism.
Movement Disorders (Incl Parkinsonism)
Tremor Familial Essential, 1
REM Sleep Behavior Disorder
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Statistical Mapping of the Brain in Progressive Supranuclear Palsy, Essential Tremor, Parkinson Disease, Parkinsonism, and REM Behavior Disorder|
- fMRI compared between cohorts [ Time Frame: one time at initial visit ] [ Designated as safety issue: No ]Studying resting brain activity between healthy adults, participants with Parkinson's and participants with REM Behavior Disorder.
|Study Start Date:||December 2011|
|Estimated Study Completion Date:||December 2018|
|Estimated Primary Completion Date:||December 2018 (Final data collection date for primary outcome measure)|
Parkinson's Disease Cohort
Individuals Diagnosed with Parkinson's Disease
Essential Tremor cohort
Individuals Diagnosed with Essential Tremor
Rapid Eye Movement Disorder Cohort
Individuals Diagnosed with Rapid-Eye Movement Behavior Disorder (RBD). Eligible individuals will have been diagnosed with RBD based on a sleep study prior to entering the study. This study does not pay for or support a sleep study.
Healthy Control group
Individuals are healthy, without a known neurologic disease.
Progressive Supranuclear Palsy Cohort
Individuals diagnosed with Progressive Supranuclear Palsy (PSP).
Parkinsonism - Undifferentiated
Individuals with any form of Parkinsonism, not meeting any of the above cohorts.
This proposal is focused on developing a reliable, valid, and reproducible imaging techniques and statistical methodology for segregation of various forms of Parkinsonism from healthy adults without Parkinsonism. We focus on early diagnosis of Parkinsonism, other tremor disorders, and determine how imaging might be used to improve diagnosis. The purpose of this protocol is to gather a multi-modal dataset to explore and validate the investigator's previous research findings in prior studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01547481
|Contact: Frank M Skidmore, MDemail@example.com|
|Contact: Paula J Spathfirstname.lastname@example.org|
|United States, Alabama|
|University of Alabama at Birmingham||Recruiting|
|Birmingham, Alabama, United States, 35294|
|Contact: Frank Skidmore, MD 205-975-3395 email@example.com|
|Principal Investigator:||Frank Skidmore, MD||University of Alabama at Birmingham|