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The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

This study has been completed.
Information provided by (Responsible Party):
Jian Kong, Massachusetts General Hospital Identifier:
First received: February 24, 2012
Last updated: February 27, 2017
Last verified: January 2017
Healthy volunteers aged 21 to 50 are needed for a research study investigating whether pain will alter the binding properties of ([11C]diprenorphine), a molecule that can be used during brain imaging. Positron Emission Tomography (PET) and functional Magnetic Resonance (fMRI) imaging will be used in this study.

Condition Intervention
Healthy Controls Radiation: PET imaging

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Other
Official Title: The Influence of Pressure Pain on [11C]Diprenorphine Binding Potentials

Further study details as provided by Jian Kong, Massachusetts General Hospital:

Primary Outcome Measures:
  • PET/MRI Brain Activation [ Time Frame: day one ]

    Simultaneously collect fMRI-PET data in humans to investigate the change between bold signal evoked by pressure pain and bold signal evoked by non-painful pressure.

    The PET analyses generates one value per 120 minutes. This value is compared to the other 120 minute scan PET value in order to reflect the change.

Enrollment: 11
Study Start Date: December 2011
Study Completion Date: December 2015
Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: healthy controls Radiation: PET imaging
Up to a 120 minute PET scan using [11C]diprenorphine as the radiotracer


Ages Eligible for Study:   21 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy male and female adults, 21 to 50 years of age
  • No contraindications to fMRI and PET scanning
  • Within 15% of ideal body mass index (BMI)

Exclusion Criteria:

  • Current significant medical, neurological, or psychiatric illness as assessed by the Physician Investigators
  • Women who are pregnant or breast feeding, have gone through menopause, and/or have irregular menstrual cycles
  • Claustrophobia
  • History of head trauma
  • Instability of responses to experimental pain (See Study Procedure Section Part II)
  • History of asthma
  • Use of psychotropic drugs or hormone treatments (including hormonal birth control) within one year of date of consent
  • History of smoking
  • Routine exercise in excess of one hour per day and/or three times per week
  • Non-fluent English speaker
  Contacts and Locations
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Please refer to this study by its identifier: NCT01546155

United States, Massachusetts
Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02139
Sponsors and Collaborators
Massachusetts General Hospital
Principal Investigator: Jian Kong, MD (equiv), MS, MPH Massachusetts General Hospital
  More Information

Responsible Party: Jian Kong, Assistant Professor, Massachusetts General Hospital Identifier: NCT01546155     History of Changes
Other Study ID Numbers: 2011P0022171
Study First Received: February 24, 2012
Results First Received: January 6, 2017
Last Updated: February 27, 2017

Additional relevant MeSH terms:
Narcotic Antagonists
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents processed this record on September 20, 2017