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Understanding the Physiological Implications of Scanning Kelvin Probe Measurements

This study has suspended participant recruitment.
(Repair of minor software glitches)
Sponsor:
ClinicalTrials.gov Identifier:
NCT01545973
First Posted: March 7, 2012
Last Update Posted: March 7, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Andrew A. Ahn, Massachusetts General Hospital
  Purpose
The purpose of this study is to evaluate the effects of skin thickness, skin moisture, and sweat gland density on Scanning Kelvin Probe measurements.

Condition Intervention
Healthy Individuals Skin Electrical Potential Other: Skin Moistening, Skin Denuding

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Measuring Skin Electrical Potential With the Kelvin Probe: Underlying Physiology

Further study details as provided by Andrew A. Ahn, Massachusetts General Hospital:

Primary Outcome Measures:
  • Surface Electrical Potential [ Time Frame: 1 day ]
    The electrical potential of skin obtained from the Scanning Kelvin Probe


Secondary Outcome Measures:
  • Electrical Impedance [ Time Frame: One day ]
    Electrical impedance (measurement) obtained through another, more conventional measurement device.


Biospecimen Retention:   Samples With DNA
Whole Blood

Estimated Enrollment: 24
Study Start Date: August 2011
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy Volunteers
Human subjects without chronic medical conditions, defined as conditions requiring chronic medication use.
Other: Skin Moistening, Skin Denuding
Application of normal saline to skin and Tape stripping of the superficial skin

Detailed Description:
The Scanning Kelvin Probe measures the electrical potential of material surfaces without actually touching it. Although this technology has been applied to non-living materials (e.g. metal and semiconductors) before, it has not been effectively applied to biological materials, much less to live human skin . This project aims to evaluate the use of Scanning Kelvin Probe to live human skin by investigating the effects of skin thickness, skin moisture, and sweat glands on Kelvin Probe measurements of electrical potential. Testing will be performed on the arms and hands of twenty four healthy individuals under different study conditions.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Healthy Volunteers
Criteria

Inclusion Criteria:

  • "Healthy" is defined as not having a chronic medical condition requiring daily medications (hypertension, diabetes, hypothyroidism, etc)

Exclusion Criteria:

  • autonomic disorders (sweating irregularities), skin disorders, extensive burns/scars on the hand, tremors, neuromuscular conditions, restless leg syndrome, movement disorders, and implanted cardiac defibrillator/pacemaker
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01545973


Locations
United States, Massachusetts
Massachusetts General Hospital - Martinos Center for Biomedical Imaging
Charlestown, Massachusetts, United States, 02129
Sponsors and Collaborators
Massachusetts General Hospital
Investigators
Principal Investigator: Andrew C. Ahn, MD, MPH Massachusetts General Hospital
  More Information

Responsible Party: Andrew A. Ahn, Assistant Professor, Massachusetts General Hospital
ClinicalTrials.gov Identifier: NCT01545973     History of Changes
Other Study ID Numbers: 55R21AT005249-02
First Submitted: March 2, 2012
First Posted: March 7, 2012
Last Update Posted: March 7, 2012
Last Verified: March 2012