Exercise and Pain Sensitivity in Knee Osteoarthritis
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|ClinicalTrials.gov Identifier: NCT01545258|
Recruitment Status : Completed
First Posted : March 6, 2012
Last Update Posted : December 2, 2016
A commonly administered conservative non-pharmacological treatment for OA is exercise, with beneficial effects in terms of reduced pain and disability.
While the link between exercise and reduced disability is mediated by e.g. increased muscle strength and endurance, the analgesic mechanisms related to exercise are unexplored. knee OA patients have both peripheral and central sensitization of pain mechanisms resulting in hyperalgesia. Thus, targeted pain treatment in these patients may focus on both peripheral and central mechanisms but it unknown if exercise affects either of these mechanisms.
It is hypothesized that in knee OA patients exercise reduces the pain sensitivity
|Condition or disease||Intervention/treatment||Phase|
|Knee Osteoarthritis||Other: Exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Single (Outcomes Assessor)|
|Primary Purpose:||Basic Science|
|Official Title:||Exercise and Changes in Pain Sensitivity in Patients With Knee Osteoarthritis|
|Study Start Date :||March 2012|
|Actual Primary Completion Date :||March 2013|
Exercise training supervised by trained physiotherapists lasting 60 minutes performed 3 times/week.
Physiotherapy supervised exercise training. 60 minutes 3 times per week
Other Name: Exercise training
|No Intervention: Control|
- Change from baseline in mechanical pain sensitivity [ Time Frame: Baseline and at 12 weeks ]Pain thresholds and temporal summation of pain
- Change from baseline in proinflammatory cytokines and biomarkers of cartilage breakdown in blood and urine [ Time Frame: Baseline and at 12 weeks ]
- Change from baseline in patient reported pain and function [ Time Frame: Baseline and at 12 weeks ]KOOS questionnaire
- Change from baseline in functional pain test [ Time Frame: Baseline and at 12 weeks ]Pain is assessed during continuous tradmill walking at self-selected pace for 20 minutes.
- Change from baseline in imaged based quantification of inflammation in the knee [ Time Frame: Baseline and at 12 weeks ]Contrast enhanced MRI imaging used to quantify inflammation (DYNAMICA software)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01545258
|The Parker Institute, Dept of rheumatology, Frederiksberg hospital|
|Copenhagen, Denmark, 2000 F|
|Principal Investigator:||Marius Henriksen, PhD||The Parker Institute, Frederiksberg Hospital|