Bone Quality by vQCT and HR-pQCT:Translation to Multi-center Clinical Research (Interscanner)
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|ClinicalTrials.gov Identifier: NCT01544660|
Recruitment Status : Completed
First Posted : March 6, 2012
Last Update Posted : April 16, 2014
|Condition or disease|
|Bone Mineral Density|
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||Bone Quality by vQCT and HR-pQCT:Translation to Multi-center Clinical Research|
|Study Start Date :||April 2012|
|Actual Primary Completion Date :||December 2013|
|Actual Study Completion Date :||March 2014|
- Develop and Validate phantoms and scanning procedures to standardize strength and structure measurements between different scanners. [ Time Frame: one visit lasting 3 hours for each subject. ]Correction of the in vivo images using the proposed inter-scanner calibration approaches will improve the quality of multi-site data by reducing the variability in CT structure and strength measures. To study the Multi-center standardization of vQCT and HR-pQCT imaging we will develop new calibration phantoms to address inter and intra-scanner variability in vQCT and HRpQCT bone strength and structure estimates.
- Development of open-source image analysis metric for vQCT [ Time Frame: Time frame will be 3 hours for a visit ]To provide standardized analysis of future clinical studies and retrospective analysis of past trials, we will develop a set of image analysis metrics for vQCT (trabecular, cortical and integral BMD, cortical thickness, cross-sectional areas, axial and bending strength estimates). These metrics will be made available to the community in an open source format, allowing them to be incorporated into commercial software platforms at the discretion of the manufacturer, incorporation as a plug-in for NIH supported programs such as MIPAV.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01544660
|United States, California|
|Department of Radiology, UCSF|
|San Francisco, California, United States, 94107|
|Principal Investigator:||Thomas Lang||University of California, San Francisco|