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Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: February 29, 2012
Last updated: May 17, 2016
Last verified: May 2016

RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.

PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.

Condition Intervention
Kidney Cancer
Genetic: DNA analysis
Genetic: fluorescence in situ hybridization
Genetic: gene expression analysis
Genetic: gene mapping
Genetic: microarray analysis
Genetic: polymerase chain reaction
Genetic: protein expression analysis
Other: laboratory biomarker analysis
Other: medical chart review

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Endogenous DNA Transposition in Rhabdoid Tumors

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • Expression and function of transposons in rhabdoid tumors

Estimated Enrollment: 50
Study Start Date: March 2012
Primary Completion Date: May 2016 (Final data collection date for primary outcome measure)
Detailed Description:


  • To investigate the expression and function of transposons in 50 primary rhabdoid tumors.

OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.


Ages Eligible for Study:   up to 1 Year   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
rhabdoid tumors


  • Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age
  • Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01544569

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Elizabeth A. Mullen, MD Dana-Farber Cancer Institute
  More Information

Responsible Party: Children's Oncology Group Identifier: NCT01544569     History of Changes
Other Study ID Numbers: AREN12B3
COG-AREN12B3 ( Other Identifier: Children's Oncology Group )
CDR0000727229 ( Other Identifier: Clinical )
AREN12B3 ( Other Identifier: Children's Oncology Group )
NCI-2012-00689 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
Study First Received: February 29, 2012
Last Updated: May 17, 2016

Keywords provided by Children's Oncology Group:
rhabdoid tumor of the kidney

Additional relevant MeSH terms:
Kidney Neoplasms
Rhabdoid Tumor
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Neoplasms, Complex and Mixed
Neoplasms by Histologic Type processed this record on April 28, 2017