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Studying Biomarkers in Samples From Young Patients With Rhabdoid Tumors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01544569
Recruitment Status : Completed
First Posted : March 6, 2012
Last Update Posted : May 18, 2016
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group

Brief Summary:

RATIONALE: Studying samples of tissue from patients with rhabdoid tumors in the laboratory may help doctor learn more about changes that occur in DNA and identify genes related to cancer.

PURPOSE: This research trial studies biomarkers in samples from young patients with rhabdoid tumors.

Condition or disease Intervention/treatment
Kidney Cancer Genetic: DNA analysis Genetic: fluorescence in situ hybridization Genetic: gene expression analysis Genetic: gene mapping Genetic: microarray analysis Genetic: polymerase chain reaction Genetic: protein expression analysis Other: laboratory biomarker analysis Other: medical chart review

Detailed Description:


  • To investigate the expression and function of transposons in 50 primary rhabdoid tumors.

OUTLINE: Freshly frozen rhabdoid tumors will be studied using fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) to establish the genomic location of transposons. Protein expression in rhabdoid tumor tissue microarrays is also analyzed.

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Endogenous DNA Transposition in Rhabdoid Tumors
Study Start Date : March 2012
Actual Primary Completion Date : May 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Kidney Cancer

Primary Outcome Measures :
  1. Expression and function of transposons in rhabdoid tumors

Information from the National Library of Medicine

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Ages Eligible for Study:   up to 1 Year   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
rhabdoid tumors


  • Freshly frozen rhabdoid tumors from either renal or extra-renal sites from children younger than 2 years of age
  • Clinical patient information (age, gender, comorbidities, tumor stage, size, pathology, therapy, outcome) available


  • Not specified


  • Not specified

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01544569

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
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Principal Investigator: Elizabeth A. Mullen, MD Dana-Farber Cancer Institute

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Responsible Party: Children's Oncology Group Identifier: NCT01544569     History of Changes
Other Study ID Numbers: AREN12B3
COG-AREN12B3 ( Other Identifier: Children's Oncology Group )
CDR0000727229 ( Other Identifier: Clinical )
AREN12B3 ( Other Identifier: Children's Oncology Group )
NCI-2012-00689 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
First Posted: March 6, 2012    Key Record Dates
Last Update Posted: May 18, 2016
Last Verified: May 2016
Keywords provided by Children's Oncology Group:
rhabdoid tumor of the kidney
Additional relevant MeSH terms:
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Kidney Neoplasms
Rhabdoid Tumor
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Kidney Diseases
Urologic Diseases
Neoplasms by Histologic Type
Neoplasms, Complex and Mixed