Effects of Exercise on sRAGE Levels and Cardiometabolic Risk Factors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01542775
Recruitment Status : Completed
First Posted : March 2, 2012
Last Update Posted : March 2, 2012
Information provided by (Responsible Party):
K. M. Choi, Korea University

Brief Summary:
The purpose of this study is to examine the effects of exercise on diverse cardiometabolic risk factors and indicators of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).

Condition or disease Intervention/treatment Phase
Type 2 Diabetes Behavioral: Aerobic Exercise Group Behavioral: Control Group Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 80 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Study Start Date : January 2010
Actual Primary Completion Date : December 2011

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Placebo Comparator: Control Behavioral: Control Group
maintaining usual activities

Active Comparator: Exercise Behavioral: Aerobic Exercise Group
12 weeks Aerobic exercise

Primary Outcome Measures :
  1. change from baseline in soluble receptor for advanced glycation endproducts (sRAGE) after 12 weeks of aerobic exercise [ Time Frame: 12 weeks ]

Secondary Outcome Measures :
  1. anthropometric parameters [ Time Frame: 12 weeks ]
    body weight, waist circumference, body fat percentage, visceral fat area

  2. biochemical parameters [ Time Frame: 12 weeks ]
    HbA1c, apolipoprotein B, free fatty acid

  3. energy expenditure [ Time Frame: 12 weeks ]
    activity energy expenditure, total energy expenditure

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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • type 2 diabetes
  • stable body weight
  • sedentary lifestyle

Exclusion Criteria:

  • smoked cigarettes
  • cardiovascular disease
  • chronic kidney
  • chronic liver disease
  • pregnant or breastfeeding
  • any other major illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01542775

Korea, Republic of
Eulji University School of Medicine
Seoul, Korea, Republic of, 139-711
Sponsors and Collaborators
Korea University

Responsible Party: K. M. Choi, Clinical Professor, Korea University Identifier: NCT01542775     History of Changes
Other Study ID Numbers: Exer(sRAGE)
First Posted: March 2, 2012    Key Record Dates
Last Update Posted: March 2, 2012
Last Verified: February 2012