Effect of Low Glycaemic Index Diet on Blood Glucose Control in Chinese Type 2 Diabetic Patients
Recruitment status was: Recruiting
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Effect of Low Glycaemic Index Diet on Blood Glucose Control in Chinese Type 2 Diabetic Patients: Randomized Controlled Trial|
- Change in blood HbA1c [ Time Frame: Baseline and week 10 ]
- Change in pre- and 2-hour post-meal capillary blood glucose concentration [ Time Frame: Baseline and week 10 ]
- Change in fasting blood glucose [ Time Frame: Baseline and week 10 ]
- Change in lipid profile ( total cholesterol, triglycerides, LDL-C, HDL-C ) [ Time Frame: Baseline and week 10 ]
- Change in blood ALT [ Time Frame: Baseline and week 10 ]
- Change in body weight [ Time Frame: Baseline and week 10 ]
- Change in blood pressure [ Time Frame: Baseline and week 10 ]
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||December 2012|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
|Experimental: Low glycaemic index diet||
Other: Low glycaemic index diet
Diabetic subjects will be given dietary advice with emphasis on low glycaemic index diet
|Active Comparator: Usual diabetic diet||
Other: Usual diabetic diet
Diabetic subjects will be given dietary advice without mention about glycaemic index
Glycaemic index (GI) is the measurement of post-meal blood glucose rise cause by ingestion of carbohydrate. For the same amount of carbohydrate, food with lower GI value cause a lower post- meal rise in blood glucose concentration in both normal and diabetic patients. Meta-analysis of randomized controlled trial has showed that low GI diet can achieve an additional reduction of A1c by 0.4% when compare with usual diabetic diet. Furthermore, various diabetes associations have already endorsed the use of low GI diet in the management of diabetes.
Hong Kong Chinese obtain most of their carbohydrate intake through consumption of rice or rice related foods, which are considered as having high GI value. In addition, it has been demonstrated that Asian have higher post-prandial rise in blood glucose than Caucasian after consuming the same amount of carbohydrate. When the above two factors add together, we expect our local type 2 diabetic patients are suffering from significant post-prandial hyperglycaemia, which in turn translate into elevated 24-hour hyperglycaemia and A1c.
However, nearly all studies about glycaemic index and diabetes are conducted in Caucasian. It is unclear about the benefit in Chinese patients with type 2 diabetes who are currently having diet with high GI value.
We therefore hypothesized that low GI diet may improve blood glucose control in Chinese type 2 diabetic patients. To test this hypothesis, we plan to conduct this randomized controlled trial about low GI diet in Chinese diabetic patients.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01542554
|China, Hong Kong SAR|
|Tung Wah Eastern Hospital, Hospital Authority|
|Hong Kong SAR, Hong Kong SAR, China|
|Principal Investigator:||Ace Lee, MBBS||Department of Medicine and Rehabilitation, Tung Wah Eastern Hospital, Hospital Authority, Hong Kong|