Studying Biomarkers in Samples From Younger Patients With Wilms Tumor
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|ClinicalTrials.gov Identifier: NCT01542333|
Recruitment Status : Completed
First Posted : March 2, 2012
Last Update Posted : May 18, 2016
RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.
|Condition or disease||Intervention/treatment|
|Kidney Cancer||Genetic: gene expression analysis Genetic: proteomic profiling Genetic: reverse transcriptase-polymerase chain reaction Genetic: western blotting Other: immunohistochemistry staining method Other: laboratory biomarker analysis Procedure: spectroscopy|
- To determine a unique molecular "finger print" of primary Wilms tumor arising in ethnically diverse children who are at increased risk to develop this lethal malignancy and subsequently relapse.
- To determine a unique protein "finger print" from the urine of ethnically diverse children who develop Wilms tumor and subsequent relapse.
OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine samples collected at the time of diagnosis and before treatment, are analyzed for molecular and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.
|Study Type :||Observational|
|Estimated Enrollment :||20 participants|
|Official Title:||Biological Analysis of Ethnic Variations in Wilms Tumor|
|Study Start Date :||February 2012|
|Actual Primary Completion Date :||May 2016|
- Molecular "finger print" of primary Wilms tumor in ethnically diverse children
- Protein "finger print" from the urine of ethnically diverse children
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01542333
|Principal Investigator:||Harold N. Lovvorn, III, MD||Vanderbilt Children's Hospital|