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Hepcidin Levels in Preterm Infants

This study has been completed.
Information provided by (Responsible Party):
Meir Medical Center Identifier:
First received: February 21, 2012
Last updated: March 15, 2016
Last verified: November 2012
A recently isolated peptide hormone, hepcidin, is thought to be the principal regulator of iron homeostasis. Hepcidin acts by limiting intestinal iron absorption and promoting iron retention in reticuloendothelial cells. The aims of this study were to determine serum hepcidin levels in preterm infants who receive blood transfusion and preterm infants having sepsis, in order to assess possible relationships between hepcidin and serum iron, serum ferritin,in iron load situations.

Preterm Infants
Anemia of Prematurity
Neonatal Sepsis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Hepcidin Levels in Preterm Infants Receiving Blood Transfusion and During Sepsis.

Resource links provided by NLM:

Further study details as provided by Meir Medical Center:

Primary Outcome Measures:
  • Increase in Hepcidin levels by 30% [ Time Frame: within 24-72 h ] [ Designated as safety issue: No ]

Enrollment: 62
Study Start Date: March 2012
Study Completion Date: August 2013
Primary Completion Date: February 2013 (Final data collection date for primary outcome measure)
preterm infants

preterm infants receiving blood transfusion

preterm infants with neonatal sepsis.


Ages Eligible for Study:   24 Weeks to 37 Weeks   (Child)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Preterm < 38 weeks gestation Need of blood transfusion according to local Protocol. or signs and symptoms of sepsis

Inclusion Criteria:

  • Preterm < 38 weeks gestation
  • Need of blood test for anemia or suspected sepsis

Exclusion Criteria:

  • Major congenital anomalies
  • Birth Asphyxia
  Contacts and Locations
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Please refer to this study by its identifier: NCT01539356

Neonatal Intensive Care Unit
Kfar-Saba, Israel, 44281
Sponsors and Collaborators
Meir Medical Center
  More Information

Responsible Party: Meir Medical Center Identifier: NCT01539356     History of Changes
Other Study ID Numbers: 0154-11-MMC 
Study First Received: February 21, 2012
Last Updated: March 15, 2016
Health Authority: Israel: Ministry of Health

Keywords provided by Meir Medical Center:
Preterm Infants

Additional relevant MeSH terms:
Premature Birth
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications
Systemic Inflammatory Response Syndrome
Pathologic Processes
Anti-Infective Agents processed this record on October 21, 2016