Blood Flow MRI for Monitoring Brain Tumors (Glioma)
The investigators are studying the use of an advanced magnetic resonance imaging (MRI) technique for measuring blood flow into brain tumors. This technique does not use radioactive tracers, and it can provide high quality images that can be obtained in a standard MRI scanner.
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Blood Flow MRI for Monitoring of Glioma Angiogenesis|
|Study Start Date:||June 2006|
|Estimated Study Completion Date:||October 2013|
|Estimated Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Our goals are:
- To compare the blood flow measured with this technique with measures of tumor blood vessel density in pieces of the tumor surgically removed as a normal part of clinical treatment. This will confirm a relationship between the imaging measurements and the microscopic characteristics of tumors.
- To compare the blood flow in tumors before therapy with the concentration of choline, an indicator of cell proliferation. This choline concentration can be measured with another MRI technique. This information will demonstrate the relationship between cell proliferation and blood supply and will also determine whether the choline measurement adds additional information that is clinically necessary.
- To determine the reproducibility of blood flow measurements in tumors. This is necessary to better understand the sensitivity of the technique to changes in flow caused by a treatment or changes in tumor vascularity.
- To monitor changes in blood flow after initial treatment. Since sometimes tumors can reappear, the repeated measures will help determine how useful this new imaging technique is at detecting such recurring tumors.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01538264
|Contact: Kelly Roth, BA||617-667-0290 ext firstname.lastname@example.org|
|Contact: Meaghan Fox, BS||617-667-5915 ext email@example.com|
|United States, Massachusetts|
|Beth Israel Deaconess Medical Center||Recruiting|
|Boston, Massachusetts, United States, 02215|
|Contact: Kelly Roth, BA 617-667-0290 ext 7-0290 firstname.lastname@example.org|
|Contact: Meaghan Fox, BS 617-667-5915 ext 7-5915 email@example.com|
|Principal Investigator: David C Alsop, PhD|
|Sub-Investigator: Rachel Scheidegger, PhD|
|Principal Investigator:||David C Alsop, PhD||Beth Israel Deaconess Medical Center|