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Microbiologic Findings of Acute Facial Palsy in Children

This study has been completed.
Helsinki University Central Hospital
Information provided by (Responsible Party):
Mervi Kanerva, Helsinki University Identifier:
First received: February 18, 2012
Last updated: February 22, 2012
Last verified: February 2012

Objective: Microbiologic etiologies of facial palsy in children were investigated.

Study design: Prospective clinical study. Methods: Forty-six children aged 0-16 years with facial palsy comprised the study group. Paired serum samples and cerebrospinal fluid were tested to find indications (antibodies, growth of the microbe, or nucleic acids) of microbes putatively associated with facial palsy. The microbes tested were herpes simplex virus-1 and -2, varicella-zoster virus, human herpesvirus-6, Mycoplasma pneumoniae, Borrelia burgdorferi, influenza A and B-, picorna-, cytomegalo-, parainfluenza-, respiratory syncytial-, coxsackie B5-, adeno-, and enteroviruses, Chlamydia psittaci, and Toxoplasma gondii. Besides the routine tests in clinical practice, serum and cerebrospinal fluid samples were tested with a highly sensitive microarray assay for DNA of herpes simplex virus-1 and -2, human herpesvirus-6A , -6B, -7, Epstein-Barr-, cytomegalo-, and varicella-zoster viruses.

Facial Paralysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Microbiologic Findings of Acute Facial Palsy in Children

Resource links provided by NLM:

Further study details as provided by Mervi Kanerva, Helsinki University:

Enrollment: 46
Study Start Date: May 2007
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   up to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Tertiary university Hospital, children 0-16 years old

Inclusion Criteria:

  • Age 0-16
  • Facial palsy
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No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Mervi Kanerva, MD, PhD, Helsinki University Identifier: NCT01537952     History of Changes
Other Study ID Numbers: 230419
Study First Received: February 18, 2012
Last Updated: February 22, 2012

Keywords provided by Mervi Kanerva, Helsinki University:
facial paralysis, facial nerve, borreliosis, Bell's palsy

Additional relevant MeSH terms:
Facial Paralysis
Bell Palsy
Disease Attributes
Pathologic Processes
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Mouth Diseases
Stomatognathic Diseases
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Facial Nerve Diseases
Cranial Nerve Diseases processed this record on September 21, 2017