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Microbiologic Findings of Acute Facial Palsy in Children

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ClinicalTrials.gov Identifier: NCT01537952
Recruitment Status : Completed
First Posted : February 23, 2012
Last Update Posted : February 23, 2012
Helsinki University Central Hospital
Information provided by (Responsible Party):
Mervi Kanerva, Helsinki University

Brief Summary:

Objective: Microbiologic etiologies of facial palsy in children were investigated.

Study design: Prospective clinical study. Methods: Forty-six children aged 0-16 years with facial palsy comprised the study group. Paired serum samples and cerebrospinal fluid were tested to find indications (antibodies, growth of the microbe, or nucleic acids) of microbes putatively associated with facial palsy. The microbes tested were herpes simplex virus-1 and -2, varicella-zoster virus, human herpesvirus-6, Mycoplasma pneumoniae, Borrelia burgdorferi, influenza A and B-, picorna-, cytomegalo-, parainfluenza-, respiratory syncytial-, coxsackie B5-, adeno-, and enteroviruses, Chlamydia psittaci, and Toxoplasma gondii. Besides the routine tests in clinical practice, serum and cerebrospinal fluid samples were tested with a highly sensitive microarray assay for DNA of herpes simplex virus-1 and -2, human herpesvirus-6A , -6B, -7, Epstein-Barr-, cytomegalo-, and varicella-zoster viruses.

Condition or disease
Facial Paralysis

Study Type : Observational
Actual Enrollment : 46 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Microbiologic Findings of Acute Facial Palsy in Children
Study Start Date : May 2007
Primary Completion Date : August 2009
Study Completion Date : August 2009

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Ages Eligible for Study:   up to 16 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Tertiary university Hospital, children 0-16 years old

Inclusion Criteria:

  • Age 0-16
  • Facial palsy

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Mervi Kanerva, MD, PhD, Helsinki University
ClinicalTrials.gov Identifier: NCT01537952     History of Changes
Other Study ID Numbers: 230419
First Posted: February 23, 2012    Key Record Dates
Last Update Posted: February 23, 2012
Last Verified: February 2012

Keywords provided by Mervi Kanerva, Helsinki University:
facial paralysis, facial nerve, borreliosis, Bell's palsy

Additional relevant MeSH terms:
Facial Paralysis
Bell Palsy
Disease Attributes
Pathologic Processes
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Mouth Diseases
Stomatognathic Diseases
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Facial Nerve Diseases
Cranial Nerve Diseases