Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Changes in Muscle Morphology Resulting From Anterior Cruciate Ligament Reconstruction

This study has been completed.
Information provided by (Responsible Party):
Panam Clinic Identifier:
First received: February 14, 2012
Last updated: March 9, 2015
Last verified: March 2015

The aim of this study is to gain new knowledge on the impact of hamstring tendon harvest and apply that knowledge to the treatment and management of patients who undergo anterior cruciate ligament (ACL) reconstruction. There are three main components of this study:

  1. How do muscle shape, size, strength, and ability to function change following hamstring grafting for ACL reconstruction;
  2. How does physical activity change following ACL reconstruction;
  3. Is there a difference in outcome if graft harvest is done from the injured versus uninjured limbs

Condition Intervention
Isolated Anterior Cruciate Ligament Rupture
Other: Autograft STG harvest from ACL-deficient leg
Other: Autograft harvest contralateral to ACL-deficient leg

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Changes in Muscle Morphology Resulting From ACL Reconstruction: Impact on Strength and Function

Resource links provided by NLM:

Further study details as provided by Panam Clinic:

Primary Outcome Measures:
  • Muscle cross sectional area [ Time Frame: 12 months post-surgery ]
    Measured on bilateral MRI taken from ischial tuberosity to 10 cm below knee joint line

Secondary Outcome Measures:
  • Knee flexion and extension isokinetic strength [ Time Frame: 12-months post-surgery ]
    Eccentric anc concentric strength measured at 60, 150, and 270 degrees/second on dynamometer in sitting and in 5 degrees hip flexion

  • Physical activity [ Time Frame: 12 months post-surgery ]
    7-day record of activity using accelerometer.

Enrollment: 30
Study Start Date: July 2009
Study Completion Date: July 2012
Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Standard
ACL reconstruction with autograft harvest of STG from ACL-deficient leg
Other: Autograft STG harvest from ACL-deficient leg
Semitendinosus-gracilis graft harvest is undertaken on same limb that is undergoing ACL reconstruction
Experimental: Autograft harvest of STG from ACL-deficient leg
Autograft harvest of STG from leg contralateral to ACL-deficient leg
Other: Autograft harvest contralateral to ACL-deficient leg
Semitendinosus-gracilis graft harvest is undertaken on limb contralateral to that undergoing ACL reconstruction
No Intervention: Normal matched


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • between 18 and 50 years old; isolated ACL rupture confirmed on MRI

Exclusion Criteria:

  • other physical or mental health issues that affect ability to complete rehabilitation and/or study follow-ups
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01537588

Canada, Manitoba
Pan Am Clinic
Winnipeg, Manitoba, Canada, R3M 3E4
Sponsors and Collaborators
Panam Clinic
Principal Investigator: Sheila McRae, MSc University of Manitoba, Pan Am Clinic Foundation
  More Information

Responsible Party: Panam Clinic Identifier: NCT01537588     History of Changes
Other Study ID Numbers: April 2009
Study First Received: February 14, 2012
Last Updated: March 9, 2015

Keywords provided by Panam Clinic:
anterior cruciate ligament

Additional relevant MeSH terms:
Wounds and Injuries processed this record on May 25, 2017