Ultrasound Perfusion Imaging After Aneurysmal Subarachnoid Hemorrhage (PSAB)
|ClinicalTrials.gov Identifier: NCT01537263|
Recruitment Status : Unknown
Verified April 2012 by Gunter Seidel, MD, Asklepios Kliniken Hamburg GmbH.
Recruitment status was: Recruiting
First Posted : February 23, 2012
Last Update Posted : April 6, 2012
|Condition or disease||Intervention/treatment|
|Aneurysmal Subarachnoid Hemorrhage||Device: Ultrasound Perfusion Imaging|
The delayed cerebral ischemia is a main complication in patient with aneurysmal subarachnoid hemorrhage which causes neurological deficit. So far there is no reliable diagnostic tool to predict the appearance of cerebral ischemia.
The causal correlation between presence of cerebral vasospasm measured daily by transcranial Doppler sonography (TCD) and occurrence of cerebral ischemia detected by cranial computed tomography scan (CCT) is not finally verified.
First studies demonstrated that ultrasound perfusion imaging (UPI) allows the detection of perfusion deficits in middle cerebral artery infarction.
The purpose of our study is to evaluate the diagnostic and prognostic value of UPI to predict delayed cerebral ischemia. In our trial we compare parameters of UPI (b= rise rate, A= plateau of acoustic intensity) in patients with aneurysmal subarachnoid hemorrhage with results of follow-up cranial computed tomography scans (CCT), TCD results and clinical outcome.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Ultrasound Perfusion Imaging After Aneurysmal Subarachnoid Hemorrhage|
|Study Start Date :||January 2012|
|Estimated Primary Completion Date :||January 2014|
|Estimated Study Completion Date :||January 2014|
Ultrasound Perfusion Imaging
Patient with subarachnoid hemorrhage.
Device: Ultrasound Perfusion Imaging
Sonographic unit Phillips IU 22, 5ml SonoVue ultrasound contrast agent per examination, Duration: 1h
- Change of perfusion [ Time Frame: Baseline, Day 5 ]Detection of hypoperfusion (defined by 50% or more reduction in beta-value of comparing day 1. with day 5.) in one or more of four regions in one or both hemispheres before the detection of delayed ischemia after SAH in CCT.
- Correlation between perfusion parameters, clinical course and flow velocities [ Time Frame: Day 1 to 90 ]Correlation between perfusion parameters (beta- and A-value), clinical course (National Institute of Health Stroke Scale - NIHSS) and flow velocities in the middle and posterior cerebral artery from day 1 to day 90.
- Change of Perfusion [ Time Frame: Baseline, Day 5 ]Detection of hypoperfusion (defined by 50% or more reduction in A-value of comparing day 1. with day 5.) in one or more of four regions in one or both hemispheres before the detection of delayed ischemia after SAH in CCT.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01537263
|Contact: Günter Seidel, MD, Professor of Neurology||0049(0)firstname.lastname@example.org|
|Department of Neurology, Asklepios Hospital North||Recruiting|
|Hamburg, Germany, 22417|
|Contact: Günter Seidel, MD, Professor of Neurology 0049(0)40 1818873076 email@example.com|
|Study Director:||Günter Seidel, MD, Professor of Neurology||Asklepios Kliniken Hamburg GmbH|