Trial record 9 of 158 for:    genetics AND Parkinson's disease

PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2) (PROGENI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01536821
Recruitment Status : Completed
First Posted : February 22, 2012
Last Update Posted : December 16, 2013
Michael J. Fox Foundation for Parkinson's Research
Information provided by (Responsible Party):
Indiana University

Brief Summary:
The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.

Condition or disease
Parkinson Disease

Detailed Description:

Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:

  1. Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.
  2. Be given a brief standard neurological examination.
  3. Be given a scratch and sniff smell identification test.
  4. Be asked to give a sample of approximately 2 tablespoons of blood.
  5. Be asked to give a urine sample of approximately 1 tablespoon of urine.

Study Type : Observational
Actual Enrollment : 81 participants
Time Perspective: Prospective
Official Title: PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study
Study Start Date : May 2011
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Observation and biological specimen collection [ Time Frame: 1 time ]

Biospecimen Retention:   Samples With DNA
DNA, plasma and serum will be obtained and stored from a blood sample. In addition, a whole blood and urine samples will be obtained and stored.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Participants must provide test results documenting a LRRK2 mutation.

Inclusion Criteria:

Positive for a LRRK2 mutation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01536821

United States, Florida
Cleveland Clinic Florida
Weston, Florida, United States, 33331
United States, Indiana
Indiana University Medical Center
Indianapolis, Indiana, United States, 46202
United States, Iowa
University of Iowa Hospitals
Iowa City, Iowa, United States, 52242
United States, Kansas
Kansas University Medical Center
Kansas City, Kansas, United States, 66160
United States, Maryland
University of Maryland School of Medicine
Baltimore, Maryland, United States, 21201
United States, Nebraska
University of Nebraska
Omaha, Nebraska, United States, 68198
United States, New York
Beth Israel Medical Center
New York, New York, United States, 10003
United States, Ohio
Medical University of Ohio
Toledo, Ohio, United States, 43614
United States, Oregon
Oregon Health & Science University
Portland, Oregon, United States, 97239
Canada, Alberta
University of Alberta
Edmonton, Alberta, Canada, T5G 0B7
Sponsors and Collaborators
Indiana University
Michael J. Fox Foundation for Parkinson's Research
Principal Investigator: Tatiana Foroud, PhD Indiana University

Additional Information:
Responsible Party: Indiana University Identifier: NCT01536821     History of Changes
Other Study ID Numbers: 1105005340
First Posted: February 22, 2012    Key Record Dates
Last Update Posted: December 16, 2013
Last Verified: April 2013

Keywords provided by Indiana University:
Parkinson disease
Parkinson's Disease

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases