PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)
The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease. Eligible participants will be asked to complete a single Study Visit at an affiliated research facility closest to their home.
|Study Design:||Time Perspective: Prospective|
|Official Title:||PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study|
- Observation and biological specimen collection [ Time Frame: 1 time ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
DNA, plasma and serum will be obtained and stored from a blood sample. In addition, a whole blood and urine samples will be obtained and stored.
|Study Start Date:||May 2011|
|Study Completion Date:||December 2013|
|Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
Participants will be asked to complete a family history questionnaire, which will gather information about their family history of Parkinson's disease and related disorders. They will be asked to complete a single Study Visit, during which they will be asked to do some or all of the following:
- Complete questionnaires regarding Parkinson's disease symptoms, medical history, mood, sleep, mental status, and activity level.
- Be given a brief standard neurological examination.
- Be given a scratch and sniff smell identification test.
- Be asked to give a sample of approximately 2 tablespoons of blood.
- Be asked to give a urine sample of approximately 1 tablespoon of urine.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01536821
|United States, Florida|
|Cleveland Clinic Florida|
|Weston, Florida, United States, 33331|
|United States, Indiana|
|Indiana University Medical Center|
|Indianapolis, Indiana, United States, 46202|
|United States, Iowa|
|University of Iowa Hospitals|
|Iowa City, Iowa, United States, 52242|
|United States, Kansas|
|Kansas University Medical Center|
|Kansas City, Kansas, United States, 66160|
|United States, Maryland|
|University of Maryland School of Medicine|
|Baltimore, Maryland, United States, 21201|
|United States, Nebraska|
|University of Nebraska|
|Omaha, Nebraska, United States, 68198|
|United States, New York|
|Beth Israel Medical Center|
|New York, New York, United States, 10003|
|United States, Ohio|
|Medical University of Ohio|
|Toledo, Ohio, United States, 43614|
|United States, Oregon|
|Oregon Health & Science University|
|Portland, Oregon, United States, 97239|
|University of Alberta|
|Edmonton, Alberta, Canada, T5G 0B7|
|Principal Investigator:||Tatiana Foroud, PhD||Indiana University|