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Interpersonal Psychotherapy for Adolescent Girls (IPT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01534377
Recruitment Status : Completed
First Posted : February 16, 2012
Last Update Posted : August 3, 2018
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Sheree Toth, University of Rochester

Brief Summary:
This study will evaluate the efficacy of Interpersonal Psychotherapy for Adolescents (IPT-A) for the treatment of depression and prevention of depression in maltreated and nonmaltreated girls between the ages of 13-15 years old.

Condition or disease Intervention/treatment Phase
Depression Behavioral: Interpersonal Psychotherapy for Adolescents Behavioral: Enhanced Care Not Applicable

Detailed Description:

Child maltreatment poses a serious public health problem and heightens the risk of psychopathology across the life course. Adolescence also represents a peak time for the emergence of depressive disorders particularly in girls. Effective interventions to prevent and treat depression in low income adolescent girls with or without histories of maltreatment are needed.

Three groups will be recruited: Maltreated Depressive Symptoms (MDS), Nonmaltreated Depressive Symptoms (NDS), and a Nonmaltreated Nonsymptomatic Comparison (NNC), comparable in SES, race/ethnicity, and household composition. The MDS and NDS groups will be randomized into IPT-A or Enhanced Care (EC). Adolescent girls in these groups will receive 13 sessions of therapy. Girls in the NNC group will only complete research visits.

Research assessments will be conducted at T1 (baseline/prior to intervention), T2 (6-weeks mid-intervention), T3 (end of intervention), T4 (1-year post) and T5 (18 months post). Girls and their mothers will participate in these research sessions. A multi-level-of-analysis approach, integrating genotyping, hormone assays, cognitive testing, adolescent- and maternal-report, mother-teen observation, and DHS and school records will be utilized to assess the effectiveness of the interventions.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 328 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Prevention of Depression in Maltreated and Nonmaltreated Adolescents
Actual Study Start Date : July 2011
Actual Primary Completion Date : June 2018
Actual Study Completion Date : June 2018

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Interpersonal Psychotherapy
Adolescents will receive Interpersonal Psychotherapy for the treatment and prevention of depression.
Behavioral: Interpersonal Psychotherapy for Adolescents
Adolescents will receive IPT-A a manualized intervention for depression and prevention of depression that emphasizes current interpersonal relationships, focusing on their immediate social context.
Other Name: IPT-A

Experimental: Enhanced Care
Adolescents will receive the Enhanced care model or care that they would typically receive in community setting to treat and prevent depression.
Behavioral: Enhanced Care
Adolescents will receive enhanced care which is consistent with care typically provided in community settings to treat and prevent depression.
Other Name: EC

Primary Outcome Measures :
  1. Change in adolescent depressive symptoms from baseline to post-intervention [ Time Frame: Baseline and 12 weeks, follow up at 1 year & again at 18 months post intervention ]
    To evaluate the efficacy of Interpersonal Psychotherapy for Adolescents (IPT-A) for decreasing depressive symptoms and preventing depression in low-income ethnically and culturally diverse adolescent girls with and without histories of child maltreatment

Information from the National Library of Medicine

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Ages Eligible for Study:   13 Years to 15 Years   (Child)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • girls
  • ages 13-15 years old
  • low SES status
  • live in Rochester or surrounding counties
  • girls in the maltreated depressive symptom group will have CPS-documented child maltreatment
  • girls in the nonmaltreated depressive symptom group will not have CPS- documented child maltreatment
  • girls in the nonmaltreated nonsymptomatic comparison group will have no current or past mental illness and no documented child maltreatment

Exclusion Criteria:

  • taking antidepressants or prescription medications for anxiety
  • already receiving mental health treatment
  • actively suicidal
  • diagnosed with a severe mental disorder
  • abusing drugs or alcohol
  • evidence of compromised cognitive ability
  • evidence of a pervasive developmental disorder
  • evidence of a major physical or neurological disorder
  • non-English speaking

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01534377

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United States, New York
Mt. Hope Family Center
Rochester, New York, United States, 14608
Sponsors and Collaborators
University of Rochester
National Institute of Mental Health (NIMH)
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Principal Investigator: Sheree Toth, PhD University of Rochester
Principal Investigator: Dante Cicchetti, Ph.D. University of Minnesota - Clinical and Translational Science Institute

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Responsible Party: Sheree Toth, Director Mt. Hope Family Center, University of Rochester Identifier: NCT01534377     History of Changes
Other Study ID Numbers: 035457
1R01MH091070-01A1 ( U.S. NIH Grant/Contract )
First Posted: February 16, 2012    Key Record Dates
Last Update Posted: August 3, 2018
Last Verified: August 2018

Keywords provided by Sheree Toth, University of Rochester:

Additional relevant MeSH terms:
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Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders