Interpersonal Psychotherapy for Adolescent Girls (IPT)
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|ClinicalTrials.gov Identifier: NCT01534377|
Recruitment Status : Completed
First Posted : February 16, 2012
Last Update Posted : August 3, 2018
|Condition or disease||Intervention/treatment||Phase|
|Depression||Behavioral: Interpersonal Psychotherapy for Adolescents Behavioral: Enhanced Care||Not Applicable|
Child maltreatment poses a serious public health problem and heightens the risk of psychopathology across the life course. Adolescence also represents a peak time for the emergence of depressive disorders particularly in girls. Effective interventions to prevent and treat depression in low income adolescent girls with or without histories of maltreatment are needed.
Three groups will be recruited: Maltreated Depressive Symptoms (MDS), Nonmaltreated Depressive Symptoms (NDS), and a Nonmaltreated Nonsymptomatic Comparison (NNC), comparable in SES, race/ethnicity, and household composition. The MDS and NDS groups will be randomized into IPT-A or Enhanced Care (EC). Adolescent girls in these groups will receive 13 sessions of therapy. Girls in the NNC group will only complete research visits.
Research assessments will be conducted at T1 (baseline/prior to intervention), T2 (6-weeks mid-intervention), T3 (end of intervention), T4 (1-year post) and T5 (18 months post). Girls and their mothers will participate in these research sessions. A multi-level-of-analysis approach, integrating genotyping, hormone assays, cognitive testing, adolescent- and maternal-report, mother-teen observation, and DHS and school records will be utilized to assess the effectiveness of the interventions.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||328 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Prevention of Depression in Maltreated and Nonmaltreated Adolescents|
|Actual Study Start Date :||July 2011|
|Actual Primary Completion Date :||June 2018|
|Actual Study Completion Date :||June 2018|
Experimental: Interpersonal Psychotherapy
Adolescents will receive Interpersonal Psychotherapy for the treatment and prevention of depression.
Behavioral: Interpersonal Psychotherapy for Adolescents
Adolescents will receive IPT-A a manualized intervention for depression and prevention of depression that emphasizes current interpersonal relationships, focusing on their immediate social context.
Other Name: IPT-A
Experimental: Enhanced Care
Adolescents will receive the Enhanced care model or care that they would typically receive in community setting to treat and prevent depression.
Behavioral: Enhanced Care
Adolescents will receive enhanced care which is consistent with care typically provided in community settings to treat and prevent depression.
Other Name: EC
- Change in adolescent depressive symptoms from baseline to post-intervention [ Time Frame: Baseline and 12 weeks, follow up at 1 year & again at 18 months post intervention ]To evaluate the efficacy of Interpersonal Psychotherapy for Adolescents (IPT-A) for decreasing depressive symptoms and preventing depression in low-income ethnically and culturally diverse adolescent girls with and without histories of child maltreatment
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01534377
|United States, New York|
|Mt. Hope Family Center|
|Rochester, New York, United States, 14608|
|Principal Investigator:||Sheree Toth, PhD||University of Rochester|
|Principal Investigator:||Dante Cicchetti, Ph.D.||University of Minnesota - Clinical and Translational Science Institute|