Cardiac-CT in the Treatment of Acute Chest Pain (CATCH)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01534000
Recruitment Status : Completed
First Posted : February 16, 2012
Last Update Posted : June 19, 2014
Information provided by (Responsible Party):
Jens D Hove, MD,PHD, Hvidovre University Hospital

Brief Summary:

Objectives The CATCH trial (CArdiac cT in the treatment of acute CHest pain) is a prospective randomized controlled trial designed to evaluate the clinical value of cardiac multidetector computed tomography (MDCT) as a first-line diagnostic strategy in patients with acute chest pain, compared to a conventional functional-based testing strategy.


Consecutive patients admitted with acute chest pain of suspected cardiac origin, but normal electrocardiogram and biomarkers were randomized to evaluation with 320-MDCT coronary angiography (CT-guided group) or with standard bicycle exercise test and/or myocardial perfusion imaging - MPI (Control group).

After one year, patients will be followed-up, with registration of clinical endpoints such as Cardiac death, myocardial infarction, need for revascularisation, admittance for heart related problems, sustained chest pain, live quality score, use of medication.

Condition or disease Intervention/treatment Phase
Ischemic Heart Disease Procedure: Cardiac computed tomographic angiography (CCTA) Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 600 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
Official Title: Cardiac-CT in the Treatment of Acute Chest Pain
Study Start Date : January 2010
Actual Primary Completion Date : January 2014
Actual Study Completion Date : January 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chest Pain

Arm Intervention/treatment
Active Comparator: CT guided group
For Patients with chest pain randomised to this arm, clinical decision will be based on the results of a Cardiac computed tomographic angiography (CCTA)
Procedure: Cardiac computed tomographic angiography (CCTA)
Patients will (on top of the standard clinical evaluation with a functional-based stress-test) be examined with a Cardiac CT scan. In the control group, the Cardiac CT will be blinded for clinical evaluation and only used retrospectively for research purpose.
Other Name: Adenosin for CT myocardial perfusion

No Intervention: Control group
Patients with chest pain randomised to the control group will be evaluated using the standard functional-based strategy with either a treadmill stress-test or SPECT (single-photon emission computed tomography). A Cardiac CT will will be performed, but will be blinded for initial clinical evaluation.

Primary Outcome Measures :
  1. combined endpoint of: Cardiac death, myocardial infarction, unstabile angina, revascularisation, readmissions for chest pain [ Time Frame: 1 year follow-up ]

Secondary Outcome Measures :
  1. Cardiac death [ Time Frame: 1 year follow-up ]
  2. myocardial infarction [ Time Frame: 1 year follow-up ]
  3. readmissions for chest pain [ Time Frame: 1 year follow-up ]
  4. Revascularisation [ Time Frame: 1 year follow-up ]
  5. unstabile angina [ Time Frame: 1-year follow-up ]
  6. continued chest pain [ Time Frame: 1 year follow-up ]
  7. Quality of life (SF-36) [ Time Frame: 1-year follow-up ]
  8. medication [ Time Frame: 1-year follow-up ]
  9. non-cardiac findings on CT [ Time Frame: 1-year follow-up ]
  10. downstream testing [ Time Frame: 1-year follow-up ]

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Admittance because of Chest pain
  • Non- or non-diagnostic ecg-changes.
  • Normal biomarkers for ischemia (Troponins)
  • Chest X-ray without pathological findings associated with chest pain.

Exclusion Criteria:

  • Women of childbearing age, or > 40 years and using approved contraception.
  • Claustrophobia
  • Patients with geographical residence, that complicates follow-up
  • Patients with mental or physical conditions that impede follow-up
  • Increase in Troponins
  • New diagnostic ECG changes with ST-segment elevation or depression greater than 1mm or T-yew inversion> 4 mm in> 2 anatomically connected derivations.
  • Allergy to iodinated contrast agents
  • Serum creatinine greater than 130 mg/l
  • Abnormal chest x-ray or blood tests hospitalization as assessed as the main cause of the patient's pain problem.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01534000

Hvidovre University Hospital
Hvidovre, Denmark, 2650
Sponsors and Collaborators
Hvidovre University Hospital
Study Director: Jesper J Linde, MD Hvidovre University Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Jens D Hove, MD,PHD, Chief of Cardiac CT, MD,PHD, Hvidovre University Hospital Identifier: NCT01534000     History of Changes
Other Study ID Numbers: H-C-2009-053
First Posted: February 16, 2012    Key Record Dates
Last Update Posted: June 19, 2014
Last Verified: June 2014

Keywords provided by Jens D Hove, MD,PHD, Hvidovre University Hospital:
Cardiac CT
Ischemic heat disease
Stress test

Additional relevant MeSH terms:
Heart Diseases
Chest Pain
Myocardial Ischemia
Coronary Artery Disease
Cardiovascular Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Vascular Diseases
Coronary Disease
Arterial Occlusive Diseases