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Oral Sodium Blood Pressure in Normal Weight, Overweight and Obese Volunteers (PLADSEL)

This study has been completed.
Information provided by (Responsible Party):
Poitiers University Hospital Identifier:
First received: February 9, 2012
Last updated: October 10, 2016
Last verified: February 2012

The primary objective of this study is to analyze the sensitivity of blood pressure to oral salt intake. Matched male and female participants will be selected as normal weight, overweight, and obese.

Participating subjects will have a first visit with blood pressure measurement and a blood sample. In two consecutive phases of one week, subjects will receive 12 pills of sodium (6 grams) or corresponding placebo. Blood pressure will be measured at the end of each phase.

Condition Intervention Phase
Obesity Other: sodium chloride Other: Methylcellulose crystalline Phase 2

Study Type: Interventional
Official Title: Simplification of the Test of Sensibility in the Salt: Preliminary Study at the Child and the Adult

Resource links provided by NLM:

Further study details as provided by Poitiers University Hospital:

Enrollment: 51
Study Start Date: March 2011
Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: chlorure de sodium Other: sodium chloride
sodium chloride 500mg
Placebo Comparator: Methylcellulose Other: Methylcellulose crystalline
Methylcellulose 37 ml


Ages Eligible for Study:   6 Years to 45 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Informed consent
  • Age 18-45 for adults and 6-8 for children

Exclusion Criteria:

  • African ethnicity (known to affect blood pressure sensitivity to salt)
  • Chronic condition affecting blood pressure
  • Diabetes (known to affect blood pressure sensitivity to salt)
  • Hypertension
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01532401

Poitiers University Hospital
Poitiers, France, 86021
Sponsors and Collaborators
Poitiers University Hospital
Principal Investigator: Samy HADJADJ, MD CHU DE POITIERS-Service d'endocrinologie
  More Information

Responsible Party: Poitiers University Hospital Identifier: NCT01532401     History of Changes
Other Study ID Numbers: PLADSEL 2010-023410-31
Study First Received: February 9, 2012
Last Updated: October 10, 2016

Keywords provided by Poitiers University Hospital:
Blood pressure processed this record on September 19, 2017