Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
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ClinicalTrials.gov Identifier: NCT01531738 |
Recruitment Status
:
Recruiting
First Posted
: February 13, 2012
Last Update Posted
: November 2, 2016
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Condition or disease |
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Obesity |
Study Type : | Observational |
Estimated Enrollment : | 20 participants |
Observational Model: | Case Control |
Time Perspective: | Prospective |
Official Title: | Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans |
Study Start Date : | July 2010 |
Estimated Primary Completion Date : | August 2018 |
Estimated Study Completion Date : | August 2018 |
Group/Cohort |
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Control
Normal weight healthy volunteers
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Gastric banding
obese patients undergoing gastric banding obesity surgery
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Gastric bypass
obese patients due to undergo gastric bypass surgery
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- Breakpoints [ Time Frame: 2 weeks pre and 8-12 weeks post operatively for surgical patients or on two occasions 10-14 weeks apart for normal weight control group ]Change in breakpoints in the last completed ratio of the computer task (breakpoints reflect the affective value of the reinforcer used)
- Hunger [ Time Frame: 2 weeks pre and 8-12 weeks post operatively for surgical patients or on two occasions 10-14 weeks apart for normal weight control group ]change in hunger levels quantified by a 100mm visual analogue scale
- Body mass index [ Time Frame: 2 weeks pre and 8-12 weeks post operatively for surgical patients or on two occasions 10-14 weeks apart for normal weight control group ]change in BMI will be quantified based on the participants weight in kilograms and height in meters

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Ages Eligible for Study: | 18 Years to 65 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- BMI of 18-25 for normal weight volunteers
- BMI of >30 for obese patients
Exclusion Criteria:
- Pregnancy
- breast feeding
- substance abuse
- consumption of more than 3 alcoholic units per day
- severe psychiatric illness
- lack of understanding of test instructions
- diabetes mellitus
- chronic medical conditions making a general anaesthetic unsafe
- allergy to stimulus ingredients
- active smoking

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01531738
Contact: Alexander D Miras, MRCP | 00442083831029 | a.miras@nhs.net |
United Kingdom | |
Imperial Weight Centre, Imperial College London | Recruiting |
London, United Kingdom, W6 8RF | |
Contact: Alexander D Miras, MRCP 00442083831029 a.miras@nhs.net | |
Sub-Investigator: Robert N Jackson, MSc |
Principal Investigator: | Carel W le Roux, MRCP PhD | Imperial College London |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Carel Le Roux, Principal Investigator, Imperial College London |
ClinicalTrials.gov Identifier: | NCT01531738 History of Changes |
Other Study ID Numbers: |
PRT |
First Posted: | February 13, 2012 Key Record Dates |
Last Update Posted: | November 2, 2016 |
Last Verified: | November 2016 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Keywords provided by Carel Le Roux, Imperial College London:
Taste bariatric surgery food preferences reward progressive ratio task |