High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure
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|ClinicalTrials.gov Identifier: NCT01531465|
Recruitment Status : Completed
First Posted : February 13, 2012
Last Update Posted : June 4, 2013
|Condition or disease||Intervention/treatment||Phase|
|Respiratory Insufficiency||Other: Pulmonary Function Testing & esophageal pressure monitoring Other: Pulmonary function testing and esophageal pressure||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Pulmonary Function Testing in Infants With Respiratory Insufficiency While Receiving High Flow Nasal Cannula (HFNC) Versus Nasal Continuous Positive Airway Pressure (nCPAP)|
|Study Start Date :||June 2011|
|Actual Primary Completion Date :||October 2012|
|Actual Study Completion Date :||January 2013|
HFNC to NCPAP
Infants who are currently on HFNC.
Other: Pulmonary function testing and esophageal pressure
Infants who are currently on HFNC will have pulmonary function testing (PFTs) and esophageal pressure performed while on 2 different settings of HFNC. These infants will then be transitioned NCPAP and will undergo PFTs and esophageal pressure while on 2 different NCPAP settings. The infant will then be returned to HFNC at the same settings they were on prior to any study interventions.
NCPAP to HFNC
Infants who are currently on NCPAP.
Other: Pulmonary Function Testing & esophageal pressure monitoring
Infants who are currently on NCPAP will have pulmonary function testing (PFTs)and esophageal pressure performed while on 2 different settings of NCPAP. These infants will then be transitioned HFNC and will undergo PFTs and esophageal pressure while on different HFNC settings. The infant will then be returned to NCPAP at the same settings they were on prior to any study interventions.
- lung compliance [ Time Frame: 2 hours ]Is there a difference in pulmonary function tests in infants with respiratory insufficiency being treated with high flow nasal cannula (HFNC) or nasal continuous positive airway pressure (NCPAP)?
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01531465
|United States, Delaware|
|Christiana Care Health System - Christiana Hospital|
|Newark, Delaware, United States, 19718|
|Principal Investigator:||Beatriz de Jongh, MD||Christiana Care Health Systems|
|Study Director:||Robert Locke, DO||Christiana Care Health Services|