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Mapping Multidimensional Illness Trajectories of Patients With End-stage Kidney Disease

This study has been completed.
National Institute of Nursing Research (NINR)
Information provided by (Responsible Party):
University of North Carolina, Chapel Hill Identifier:
First received: February 7, 2012
Last updated: September 2, 2015
Last verified: September 2015
Patients with end-stage kidney disease (ESKD) must manage not only the demands of dialysis and comorbid conditions but also associated symptoms and acute life-threatening events that contribute to functional limitations and increased risk of mortality. Yet little is known about the trajectories of quality of life dimensions in patients with ESKD when they experience acute life-threatening episodes, to guide palliative care for this population. In this prospective, descriptive study, we will identify trajectories of symptoms, physical functioning, psychosocial needs, and emotional and spiritual well-being in 200 patients with ESKD who are at a high risk of experiencing acute life-threatening events and mortality within 12 months.

End Stage Kidney Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Mapping Multidimensional Illness Trajectories of Patients With ESKD

Resource links provided by NLM:

Further study details as provided by University of North Carolina, Chapel Hill:

Primary Outcome Measures:
  • Symptoms, physical functioning, psychosocial needs, spiritual well-being, cognitive functioning [ Time Frame: 12 months ]

Enrollment: 227
Study Start Date: March 2012
Study Completion Date: July 2015
Primary Completion Date: July 2015 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
ESKD patients who have been on dialysis

Inclusion Criteria:

  • aged 18 years or older;
  • receiving either Hemodialysis or Peritoneal dialysis
  • on dialysis either < 3 months or ≥ 6 months with a Charlson Comorbidity Index (CCI) score ≥ 5

Exclusion Criteria:

  • Patients who are enrolled in hospice or too sick to participate in questionnaire completion will not be eligible.
  • Kidney transplant candidates will be excluded because their illness trajectories after transplant are likely to differ.
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Please refer to this study by its identifier: NCT01530945

United States, North Carolina
UNC Hospitals and outpatient dialysis clinics
Chapel Hill, North Carolina, United States, 27514
Sponsors and Collaborators
University of North Carolina, Chapel Hill
National Institute of Nursing Research (NINR)
Principal Investigator: Mi-Kyung Song, PhD, RN, FAAN University of North Carolina, Chapel Hill
  More Information

Responsible Party: University of North Carolina, Chapel Hill Identifier: NCT01530945     History of Changes
Other Study ID Numbers: R01NR013359 ( US NIH Grant/Contract Award Number )
Study First Received: February 7, 2012
Last Updated: September 2, 2015

Additional relevant MeSH terms:
Kidney Diseases
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency processed this record on May 24, 2017