Metformin for the Treatment of Unexplained Oligozspermia
|ClinicalTrials.gov Identifier: NCT01529177|
Recruitment Status : Unknown
Verified August 2015 by Ragaa Mansour, The Egyptian IVF-ET Center.
Recruitment status was: Recruiting
First Posted : February 8, 2012
Last Update Posted : August 7, 2015
|Condition or disease||Intervention/treatment||Phase|
|Infertility||Drug: Metformin / clomid / hCG Drug: Clomiphene citrate / hCG||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||600 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia|
|Study Start Date :||February 2012|
|Estimated Primary Completion Date :||September 2016|
|Estimated Study Completion Date :||February 2017|
Experimental: Metformin / clomid / hCG
Metformin 1000 mg orally to be given daily for one week then twice daily for 2 weeks then 3 times daily for 6 months.
After 3 months from starting metformin the participant will receive 2 more medications in addition to metformin:
Clomid 50 mg orally per day and 5000 IU human chorionic gonadotrophin (hCG ) IM once per week for three months.
Drug: Metformin / clomid / hCG
Metformin 1000 mg daily for a week then twice daily for 2 weeks then 3 tomes daily for 6 months.
Other Name: Glucophage / clomiphene citrate / choriomon
Experimental: Clomid / hCG
Clomid 50 mg per day will be administered orally and human chorionic gonadotrophin ( choriomon ) 5000 IU will be administered IM once per week. Both medications will be given for 6 month.
Drug: Clomiphene citrate / hCG
Clomiphene citrate 50 mg daily for one month, then twice daily for 2 months then 3 times per day for 3 months.
Other Name: Clomid / choriomon
- sperm count [ Time Frame: 6 months ]semen analysis before the start of metformin and then every month for 6 months
- abnormal forms of spermatozoa [ Time Frame: 6 months ]semen analysis before the start of metformin and then every month for 6 months
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01529177
|The Egyptian IVF-ET center||Recruiting|
|Cairo, Egypt, 11431|
|Contact: Ragaa mansour 20225254955 firstname.lastname@example.org|
|Principal Investigator: Ragaa mansour, MD,PhD|
|Principal Investigator:||Ragaa mansour, MD,PhD||The Egyptian IVF-ET Center|