Studying Genes in Samples From Younger Patients With Adrenocortical Tumor
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.
|Adrenocortical Carcinoma||Genetic: DNA methylation analysis Genetic: RNA analysis Genetic: gene expression analysis Genetic: nucleic acid sequencing Genetic: polymorphism analysis|
|Study Design:||Observational Model: Case-Only
Time Perspective: Retrospective
|Official Title:||Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0|
- Identification of genetic factors affecting adrenocortical tumors
- Comprehensive catalog of altered genes in adrenocortical samples
|Study Start Date:||February 2012|
|Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
- To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells.
OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01528956
|Principal Investigator:||Gerard Zambetti, PhD||St. Jude Children's Research Hospital|