We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01528748
First Posted: February 8, 2012
Last Update Posted: October 27, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Jennifer Kim Penberthy, University of Virginia
  Purpose
This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent.

Condition Intervention
Depressive Disorder Major Depressive Disorder Dysthymic Disorder Alcohol-Related Disorders Alcoholism Behavioral: Cognitive Behavioral Analysis System of Psychotherapy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence

Resource links provided by NLM:


Further study details as provided by Jennifer Kim Penberthy, University of Virginia:

Primary Outcome Measures:
  • Depression Rating [ Time Frame: Baseline and 20 weeks ]
    Change in depression rating scale over time.

  • Drinking behavior [ Time Frame: Baseline and 20 weeks ]
    Change in number of drinks consumed per day over time.


Enrollment: 8
Study Start Date: April 2011
Estimated Study Completion Date: July 2018
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Chronically Depressed, Alcohol Dependent
Participants who have been formally diagnosed with a clinical diagnosis of Chronic Depression and Alcohol Dependence.
Behavioral: Cognitive Behavioral Analysis System of Psychotherapy
Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a behavioral intervention that addresses the unique behavioral characteristics of chronically depressed individuals, most of which are highly relevant for alcoholics as well. CBASP has a structured, individualized, and collaborative (patient and clinician) design. The intervention emphasizes teaching effective coping strategies and employing motivational, cognitive, behavioral, and interpersonal techniques. Individual therapy (1 hour) sessions occur on a weekly basis for a total of 20 sessions over a period of 21 weeks.
Other Name: CBASP

Detailed Description:
This study examines the effectiveness of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) in reducing both alcohol consumption and depressive symptoms in adults who are chronically depressed and alcohol dependent. Participants will receive a 20-session course of CBASP psychotherapy over a period of 21 weeks and will be assessed for severity of pretreatment psychological abuse and trauma as well as pre and posttreatment interpersonal functioning. Two primary hypotheses are to be tested: 1) demonstrate that CBASP is effective in reducing depressive symptoms (Hamilton Rating Scale for Depression-24 ratings) and alcohol consumption (drinks per drinking day) in this chronically depressed alcohol dependent cohort when posttreatment ratings are compared to pretreatment levels; and 2) demonstrate that acquisition of feeling safe with the therapist and acquisition of the ability to perceive the interpersonal consequences of one's behavior will significantly increase from pre to posttreatment levels and will be associated with reductions in drinking and depressive symptoms.
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   21 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Participants will be recruited via a community sample.
Criteria

Inclusion Criteria:

  • Clinical diagnosis of a current major depressive disorder (e.g., Major Depression, Dysthymic Disorder) for a minimum of two years
  • Clinical diagnosis of alcohol dependence during the last thirty days
  • Interest in changing one's drinking and alleviating depressive symptoms

Exclusion Criteria:

  • Please call study site for additional information
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01528748


Locations
United States, Virginia
University of Virginia Center for Addiction Research & Education (UVa CARE)
Charlottesville, Virginia, United States, 22911
Sponsors and Collaborators
University of Virginia
Investigators
Principal Investigator: Jennifer K. Penberthy, Ph.D. University of Virginia, School of Medicine, Department of Psychiatry & Neurobehavioral Sciences
  More Information

Publications:
McCullough, Jr., JP. (2000). Treatment for Chronic Depression: Cognitive Behavioral Analysis System of Psychotherapy (CBASP). New York: Guilford Press.
McCullough, Jr., JP. (2001). Skills Training Manual for Diagnosis and Treating Chronic Depression: Cognitive Behavioral Analysis System of Psychotherapy (CBASP). New York: Guilford Press.

Responsible Party: Jennifer Kim Penberthy, Associate Professor, School of Medicine, University of Virginia
ClinicalTrials.gov Identifier: NCT01528748     History of Changes
Other Study ID Numbers: 15599
First Submitted: February 4, 2012
First Posted: February 8, 2012
Last Update Posted: October 27, 2016
Last Verified: October 2016

Additional relevant MeSH terms:
Disease
Depression
Depressive Disorder
Depressive Disorder, Major
Alcoholism
Alcohol-Related Disorders
Dysthymic Disorder
Pathologic Processes
Behavioral Symptoms
Mood Disorders
Mental Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Ethanol
Anti-Infective Agents, Local
Anti-Infective Agents
Central Nervous System Depressants
Physiological Effects of Drugs