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Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study (CUPID)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2012 by Thailand Research Fund.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Wanwarang Wongcharoen, MD., Thailand Research Fund Identifier:
First received: January 31, 2012
Last updated: February 7, 2012
Last verified: February 2012
It is well-established that myocardial infarction (MI) associated with coronary artery bypass graft surgery (CABG) predicts the poor outcome. Nevertheless, the cardioprotective therapies to limit myocardial injury after CABG are lacking. Previous studies have shown that curcuminoids suppress pro-inflammatory cytokines during cardiopulmonary bypass surgery and decrease the occurrence of cardiomyocytic apoptosis after cardiac ischemia/reperfusion injury in animal models. The investigators aim to evaluate whether curcuminoids prevent MI after CABG, compared to placebo.

Condition Intervention Phase
Coronary Artery Bypass Grafting
Dietary Supplement: Curcuminoids
Other: Placebo
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Effects of CUrcuminoids on Coronary Artery byPass graftIng-related myocarDial Infarction Study

Resource links provided by NLM:

Further study details as provided by Thailand Research Fund:

Primary Outcome Measures:
  • Incidence of postoperative myocardial infarction [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 10 days ]

Estimated Enrollment: 200
Study Start Date: September 2009
Estimated Study Completion Date: December 2012
Primary Completion Date: September 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Curcuminoids Dietary Supplement: Curcuminoids
Curcuminoids in capsule form, 4 capsules four times daily (4 grams/day)
Placebo Comparator: Placebo Other: Placebo
Placebo in capsule form, 4 capsules 4 times/day


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Patients undergoing CABG without valve surgery

Exclusion Criteria:

  • emergency cardiac surgery
  • any increase in CK-MB above upper limit of normal range (ULN) at the time of randomization
  • patients with cholestatic jaundice (total bilirubin > 2-fold ULN)
  • severe liver disease (AST or ALT > 3-fold ULN)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01528514

Contact: Wanwarang Wongcharoen, MD +66 53 946713

Maharaj Nakorn Chiang Mai hospital Recruiting
Muang, Chiang Mai, Thailand, 50210
Contact: Wanwarang Wongcharoen, MD    +66 53 946713   
Principal Investigator: Wanwarang Wongcharoen, MD         
Sponsors and Collaborators
Wanwarang Wongcharoen, MD.
Principal Investigator: Wanwarang Wongcharoen, MD Faculty of Medicine, Chiang Mai university
  More Information

Responsible Party: Wanwarang Wongcharoen, MD., Principal investigator, Thailand Research Fund Identifier: NCT01528514     History of Changes
Other Study ID Numbers: MRG5380258
Study First Received: January 31, 2012
Last Updated: February 7, 2012

Keywords provided by Thailand Research Fund:
Myocardial infarction
Coronary artery bypass grafting

Additional relevant MeSH terms:
Myocardial Infarction
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases processed this record on May 23, 2017