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Comparison of Bowel Cleansing Methods for Colonoscopy in Hospitalized Patients (PEG)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2012 by Kangbuk Samsung Hospital.
Recruitment status was:  Not yet recruiting
Soon Chun Hyang University
Kyunghee University
Hanyang University
Information provided by (Responsible Party):
Dong Il Park, M.D, Ph.D., Kangbuk Samsung Hospital Identifier:
First received: February 3, 2012
Last updated: February 20, 2012
Last verified: February 2012
The purpose of this study is to compare two regimens of polyethylene glycol(PEG) plus bisacodyl versus PEG alone for bowel preparation in hospitalized patients.

Intestine; Complaints

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Efficacy of Bisacodyl Given as Part of a Polyethylene Glycol-based Bowel Preparation Prior to Colonoscopy in Hospitalized Patients

Resource links provided by NLM:

Further study details as provided by Kangbuk Samsung Hospital:

Primary Outcome Measures:
  • The efficacy of bowel preparation [ Time Frame: one day (after colonoscopy) ]
    Ottawa scale

Secondary Outcome Measures:
  • Patient's compliance and acceptability [ Time Frame: one day (after injestion of preparation solution) ]
    acceptability, Visual Analogue Scale

  • Patient's compliance and acceptability (2) [ Time Frame: one day (after injestion of preparation solution) ]
    stress for ingestion, Stress 0(not) - 4(severe)

  • Patient's compliance and acceptability (3) [ Time Frame: one day (after colonoscopy) ]
    willingness for re-evaluation, 0(very willing) - 4(some)

Estimated Enrollment: 600
Study Start Date: March 2012
Estimated Study Completion Date: October 2012
Estimated Primary Completion Date: July 2012 (Final data collection date for primary outcome measure)
PEG plus bisacodyl
Those who taken PEG 4L + bisacodyl 10mg
Those who taken PEG 4L alone

Detailed Description:
Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage without producing significant fluid or electrolyte changes. Thus PEG is now commonly used for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are generally poorly tolerated, especially in hospitalized patients who had comorbidity and restricted ambulation. Recently, a new PEG-based bowel cleansing agents became available. It combines PEG with a high dose of ascorbic acid or bisacodyl. Although many studies reported the efficacy of these combined solution for colonoscopy, but efficacy in hospitalized patients was under-recognized.

Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Hospitalized patients for colonoscopy in university hospital.

Inclusion Criteria:

  • Hospitalized patients for colonoscopy

Exclusion Criteria:

  • age under 20 years or over 80 years
  • major psychiatric illness
  • known allergy to PEG
  • serious condition- severe cardiac, renal, or metabolic diseases
  • partial colon resection
  • current acute exacerbation of chronic inflammatory bowel disease
  • functional constipation defined by Rome III diagnostic criteria
  Contacts and Locations
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Please refer to this study by its identifier: NCT01528098

Contact: Dong Il Park, professor 82-2-2001-2059

Sponsors and Collaborators
Kangbuk Samsung Hospital
Soon Chun Hyang University
Kyunghee University
Hanyang University
Principal Investigator: Dong Il Park, Professor Kangbuk Samsung Hospital
  More Information

Responsible Party: Dong Il Park, M.D, Ph.D., Associate professor, Department of Internal Medicine, Kangbuk Samsung Hospital Identifier: NCT01528098     History of Changes
Other Study ID Numbers: PEGPD
Study First Received: February 3, 2012
Last Updated: February 20, 2012

Keywords provided by Kangbuk Samsung Hospital:
polyethylene glycol

Additional relevant MeSH terms:
Gastrointestinal Agents
Laxatives processed this record on April 28, 2017