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Trial record 4 of 1057 for:    hypertension AND (woman OR women OR female)

Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension

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ClinicalTrials.gov Identifier: NCT01523327
Recruitment Status : Unknown
Verified January 2012 by nermin marzouk agaibi, Ain Shams Maternity Hospital.
Recruitment status was:  Recruiting
First Posted : February 1, 2012
Last Update Posted : February 1, 2012
Sponsor:
Information provided by (Responsible Party):
nermin marzouk agaibi, Ain Shams Maternity Hospital

Brief Summary:
Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension.

Condition or disease Intervention/treatment
Uric Acid and Hypertension in Pregnancy Other: measuring protein creatinin ratio,serum uric acid

Detailed Description:
Association of maternal uric acid with maternal condition(renal function,liver function,...ect.) and fetal outcome(birth weight,APGER score) in pregnant women with hypertension.

Study Type : Observational
Estimated Enrollment : 80 participants
Time Perspective: Cross-Sectional
Official Title: Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension
Study Start Date : October 2011
Actual Primary Completion Date : November 2011
Estimated Study Completion Date : October 2012

Resource links provided by the National Library of Medicine

Drug Information available for: Uric Acid
U.S. FDA Resources

Group/Cohort Intervention/treatment
A
40 pregnant Women with hypertension who have uric acid level more than 6 mg per dL.
Other: measuring protein creatinin ratio,serum uric acid

A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate.

Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.

B
40 pregnant women with hypertension who have uric acid level less than 6 mg per dl.
Other: measuring protein creatinin ratio,serum uric acid

A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate.

Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.





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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The study will include 80 pregnant ladies with hypertension admitted to the maternity ward of the hospital who will be divided into two groups according to their uric acid level.
Criteria

Inclusion Criteria:

  • Age:18-40 years old
  • Gestational age:28-42 weeks gestation singleton pregnancy of living fetus
  • Non smoker

Exclusion Criteria:

  • women who refuse the study
  • Any medical or obstetric disorders especially D.M.,renal disease,hepatic, cardiac disorders or gout arthritis, other than hypertension if present.
  • Previously elevated uric acid level.
  • Hemolytic or sickle cell anemia,urinary tract infection.
  • Use of diuretics or anti-inflammatory drugs.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01523327


Contacts
Contact: Nermin marzouk touma, M.B.,B.Ch 01222740182 ext 002 nermindave@gmail.com
Contact: nermin Marzouk touma, M.B.,B.Ch 0862636607 ext 002 nermindave@gmail.com

Locations
Egypt
Ain shams maternity hospital Recruiting
Cairo, Egypt, 11117
Principal Investigator: nermin marzouk touma, M.B.,B.Ch         
Sponsors and Collaborators
Ain Shams Maternity Hospital
Investigators
Study Director: Mohamed Saeedeldin Elsafty, assistant lecture Ain Shams Maternity Hospital

Additional Information:
Publications of Results:
Responsible Party: nermin marzouk agaibi, Nermin Marzouk Agaibi, Ain Shams Maternity Hospital
ClinicalTrials.gov Identifier: NCT01523327     History of Changes
Other Study ID Numbers: ainshamsMH
First Posted: February 1, 2012    Key Record Dates
Last Update Posted: February 1, 2012
Last Verified: January 2012

Keywords provided by nermin marzouk agaibi, Ain Shams Maternity Hospital:
Uric acid

Additional relevant MeSH terms:
Hypertension
Hypertension, Pregnancy-Induced
Pre-Eclampsia
Vascular Diseases
Cardiovascular Diseases
Pregnancy Complications
Uric Acid
Antioxidants
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs