Study of Association Between Maternal Uric Acid , Maternal and Fetal Outcome in Pregnant Women With Hypertension

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

Association of maternal uric acid with maternal condition and fetal outcome in pregnant women with hypertension.

Condition or disease	Intervention/treatment
Uric Acid and Hypertension in Pregnancy	Other: measuring protein creatinin ratio,serum uric acid

Detailed Description:

Association of maternal uric acid with maternal condition(renal function,liver function,...ect.) and fetal outcome(birth weight,APGER score) in pregnant women with hypertension.

Study Design

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type :	Observational
Estimated Enrollment :	80 participants
Time Perspective:	Cross-Sectional
Official Title:	Association of Maternal Uric Acid With Maternal Condition and Fetal Outcome in Pregnant Women With Hypertension
Study Start Date :	October 2011
Actual Primary Completion Date :	November 2011
Estimated Study Completion Date :	October 2012

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort	Intervention/treatment
A; 40 pregnant Women with hypertension who have uric acid level more than 6 mg per dL.	Other: measuring protein creatinin ratio,serum uric acid; A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate. Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.
B; 40 pregnant women with hypertension who have uric acid level less than 6 mg per dl.	Other: measuring protein creatinin ratio,serum uric acid; A non-deproteinized Jaffe reaction is employed to measure creatinine and urinary protein measured by an automated colorimetric assay using pyrogallol red and sodium molybdate. Measuring of serum uric acid by(2,4,6-tribromo-3-hydroxybenzoic acid)TBHBA by uricase method.

Outcome Measures

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Eligibility Criteria

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	18 Years to 40 Years (Adult)
Sexes Eligible for Study:	Female
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

The study will include 80 pregnant ladies with hypertension admitted to the maternity ward of the hospital who will be divided into two groups according to their uric acid level.

Criteria

Inclusion Criteria:

• Age:18-40 years old
• Gestational age:28-42 weeks gestation singleton pregnancy of living fetus
• Non smoker

Exclusion Criteria:

• women who refuse the study
• Any medical or obstetric disorders especially D.M.,renal disease,hepatic, cardiac disorders or gout arthritis, other than hypertension if present.
• Previously elevated uric acid level.
• Hemolytic or sickle cell anemia,urinary tract infection.
• Use of diuretics or anti-inflammatory drugs.

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Contacts

Contact: Nermin marzouk touma, M.B.,B.Ch	01222740182 ext 002	nermindave@gmail.com
Contact: nermin Marzouk touma, M.B.,B.Ch	0862636607 ext 002	nermindave@gmail.com

Locations

Egypt
Ain shams maternity hospital	Recruiting
Cairo, Egypt, 11117
Principal Investigator: nermin marzouk touma, M.B.,B.Ch

Sponsors and Collaborators

Ain Shams Maternity Hospital

Investigators

Study Director:	Mohamed Saeedeldin Elsafty, assistant lecture	Ain Shams Maternity Hospital

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Additional Information:

does+uric+acid+provide+information+about+maternal+condition+and+fetal+outcome+in+pregnant+women+with+hypertension&TransSchema=title&cmd=detailssearch 

does+uric+acid+provide+information+about+maternal+condition+and+fetal+outcome+in+pregnant+women+with+hypertension&TransSchema=title&cmd=detailssearch 

Publications of Results:

MATSELIUKH BP. [TRANSMISSION OF CERTAIN BIOCHEMICAL PROPERTIES IN ACTINOMYCETES BY MEANS OF DNA UNDER CONDITIONS OF HETEROTRANSFORMATION]. Mikrobiol Zh. 1963;25:3-6. Russian.

Paula LG, da Costa BE, Poli-de-Figueiredo CE, Antonello IC. Does uric acid provide information about maternal condition and fetal outcome in pregnant women with hypertension? Hypertens Pregnancy. 2008;27(4):413-20. doi: 10.1080/10641950801955709.

Responsible Party:	nermin marzouk agaibi, Nermin Marzouk Agaibi, Ain Shams Maternity Hospital
ClinicalTrials.gov Identifier:	NCT01523327 History of Changes
Other Study ID Numbers:	ainshamsMH
First Posted:	February 1, 2012
Last Update Posted:	February 1, 2012
Last Verified:	January 2012

Keywords provided by nermin marzouk agaibi, Ain Shams Maternity Hospital:

Uric acid

Additional relevant MeSH terms:

Hypertension; Hypertension, Pregnancy-Induced; Pre-Eclampsia; Vascular Diseases; Cardiovascular Diseases; Pregnancy Complications	Uric Acid; Antioxidants; Molecular Mechanisms of Pharmacological Action; Protective Agents; Physiological Effects of Drugs