Preventing Myocardial Ischemia by Preconditioning in Elective Operation for Abdominal Aortic Aneurysm
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ClinicalTrials.gov Identifier: NCT01523262 |
Recruitment Status
: Unknown
Verified January 2015 by Nikolaj Eldrup, Aarhus University Hospital.
Recruitment status was: Recruiting
First Posted
: February 1, 2012
Last Update Posted
: January 14, 2015
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Primary To investigate whether peripheral predonditioning induced by brief, intermittent constriction of blood supply to an arm can reduce the incidence of perioperative myocardial ischemia in patients operated electively for infrarenal aortic aneurysm.
Secondary To investigate the impact of peripheral preconditioning on perioperative inflammatory response.
To investigate whether peripheral preconditoning can protect against perioperative myocardial infarction and reduced cardiac pump function.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Aortic Aneurysm | Procedure: preconditioning Procedure: Normal surgery, with sham intervention without inflating arm cuff | Phase 1 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 200 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | The Effect of Preconditioning to Prevent Perioperative Myocardial Ischemia in Elective Operation of Abdominal Aortic Aneurysm |
Study Start Date : | January 2011 |
Estimated Primary Completion Date : | January 2015 |
Estimated Study Completion Date : | January 2016 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Preconditioning and normal treatment |
Procedure: preconditioning
peripheral preconditioning induced by brief, intermittent constriction of blood supply to an arm
|
Placebo Comparator: normal treatment
Standard treatment
|
Procedure: Normal surgery, with sham intervention without inflating arm cuff |
- measurements of CKMB and Troponin T [ Time Frame: 30 days ]

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- All patients older than 18 years, hospitalized for elective surgery of abdominal aortic aneurysm
Exclusion Criteria:
- Lack of informed consent.
- Hemiparetic patient.
- Pregnancy or nursing patient.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01523262
Denmark | |
Aarhus University Hospital, Skejby | Recruiting |
Aarhus, Aarhus N, Denmark, 8200 | |
Contact: Nikolaj Eldrup eldrup@clin.au.dk | |
Sub-Investigator: Nikolaj Eldrup, MD, PHD | |
Aalborg Hospital | Not yet recruiting |
Aalborg, Denmark, 9000 | |
Contact: Troels F Pedersen, MD troels.fogh@ki.au.dk | |
Principal Investigator: Troels F Pedersen, MD |
Responsible Party: | Nikolaj Eldrup, MD, PHD, Aarhus University Hospital |
ClinicalTrials.gov Identifier: | NCT01523262 History of Changes |
Other Study ID Numbers: |
M-20100012 |
First Posted: | February 1, 2012 Key Record Dates |
Last Update Posted: | January 14, 2015 |
Last Verified: | January 2015 |
Keywords provided by Nikolaj Eldrup, Aarhus University Hospital:
preconditioning aortic aneurysm |
Additional relevant MeSH terms:
Ischemia Aneurysm Aortic Aneurysm Myocardial Ischemia Coronary Artery Disease Aortic Aneurysm, Abdominal Pathologic Processes |
Vascular Diseases Cardiovascular Diseases Aortic Diseases Heart Diseases Coronary Disease Arteriosclerosis Arterial Occlusive Diseases |