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Atrial and Brain Natriuretic Peptide Secretion After Percutaneous Closure of the Left Atrial Appendage

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2012 by University of Leipzig.
Recruitment status was:  Active, not recruiting
Information provided by (Responsible Party):
Nicolas Majunke, University of Leipzig Identifier:
First received: December 20, 2011
Last updated: January 30, 2012
Last verified: January 2012
To date there are no data suggesting substantial effects of hormonal interaction after percutaneous closure of the left atrial appendage (LAA). Our hypothesis is that by excluding the LAA from blood flow physiologic stimuli for ANP and BNP produce may be impaired and consecutive release of the hormones may be reduced. Here, we present our experience of ANP and BNP secretion in the early postprocedural period after transcatheter closure of the LAA.

Condition Intervention
Atrial Fibrillation
Stroke Prevention
Left Atrial Appendage
Device: WATCHMAN LAA system (Percutaneous left atrial appendage closure)

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Interventional Study to Investigate the Effects of Percutaneous Closure of the Left Atrial Appendage on Atrial and Brain Natriuretic Peptide Secretion

Resource links provided by NLM:

Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • Change from Baseline Plasma ANP and BNP levels after transcatheter closure of the left atrial appendage. [ Time Frame: participants will be followed for the duration of hospital stay, an expected average of 48 hours ]
    Venous blood samples are taken before the procedure, immediately after implantation of the LAA closure device and on the first morning after the procedure. The blood is drawn into plastic tubes containing aprotinin and ethylenediaminetetraacetic acid disodium and is promptly centrifuged. The plasma obtained is stored at -20°C until assayed. The plasma BNP and ANP concentrations are then determined with a commercially available enzyme immunoassay kit (ELISA Kit for Brain Natriuretic Peptide, Uscn Life Science Inc., Missouri City, USA and ANP ELISA Kit, Hölzel Diagnostika, Köln, Germany).

Estimated Enrollment: 50
Study Start Date: May 2010
Estimated Study Completion Date: January 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
atrial and brain natriuretic peptide
Impact on atrial an brain natriuretic peptide secretion after percutaneous left atrial appendage closure
Device: WATCHMAN LAA system (Percutaneous left atrial appendage closure)
The WATCHMAN LAA system (Altritech Inc., Plymouth, MN),Percutaneous occlusion systems have been developed as an alternative to anticoagulation for stroke prevention. Briefly, transseptal puncture is performed to gain access to the left atrial appendage (LAA). Thereafter LAA angiography is performed. After an optimal device size is chosen based on LAA measurements by fluoro and echocardiography the occluder is implanted into the orifice of the left atrial appendage under fluoroscopy and TEE-guidance. The size of the device is chosen to be 10% to 20% larger than diameter of the LAA ostium to have stable positioning of the device. Every procedure is performed under local anaesthesia. Heparin is given during implantation procedure to achieve an activated clotting time of at least 250.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • non-valvular atrial fibrillation
  • increased risk for thromboembolic complications (a minimum CHADS2Score of at least 2)

Exclusion Criteria:

  • Valvular-atrial fibrillation
  • Low risk for thromboembolic complications CHADS-2-Score < 2
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Please refer to this study by its identifier: NCT01522911

Sponsors and Collaborators
University of Leipzig
Principal Investigator: Nicolas Majunke, M.D. HearCenter Leipzig
Principal Investigator: Sven Moebius-Winkler, M.D. HearCenter Leipzig
Principal Investigator: Gerhard Schuler, Professor HearCenter Leipzig
  More Information

Responsible Party: Nicolas Majunke, senior physician, University of Leipzig Identifier: NCT01522911     History of Changes
Other Study ID Numbers: LAA-1
Study First Received: December 20, 2011
Last Updated: January 30, 2012

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Natriuretic Peptide, Brain
Natriuretic Agents
Physiological Effects of Drugs processed this record on April 27, 2017