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Natural History of Carotid Atherosclerosis

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2015 by University of Athens
Information provided by (Responsible Party):
Konstantinos Toutouzas, University of Athens Identifier:
First received: January 25, 2012
Last updated: May 26, 2015
Last verified: May 2015
A prospective study of 700 patients with coronary artery disease will undergo non invasive evaluation of their carotid arteries by ultrasound and microwave radiometry. The patients will be followed up for 3 years and their outcome regarding the cardiovascular events (death, cardiac events, cerebrovascular events) will be recorded

Carotid Artery Disease
Myocardial Infarction
Angina Pectoris

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Natural History Study of Carotid Atherosclerosis

Resource links provided by NLM:

Further study details as provided by University of Athens:

Primary Outcome Measures:
  • To detect if carotid ultrasound and carotid microwave radiometry measurements can predict the incidence of cerebrovascular and cardiovascular events in patients with coronary artery disease [ Time Frame: 3 years ]
    Microwave radiometry is a non invasive and safe technique that measures temperature of the internal tissues by detecting the normal radiation of the tissues in microwave frequencies. The primary outcome of the study is to see if the temperatures measured in the carotid arteries of patients with coronary artery disease can predict their outcome regarding cerebrovascular and cardiovascular events

Secondary Outcome Measures:
  • Relation of other demographic factors with carotid ultrasound and microwave radiometry measurements and outcome [ Time Frame: 3 years ]

Estimated Enrollment: 700
Study Start Date: January 2012
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
carotid thermal heterogeneity
Patients that have carotid thermal heterogeneity detected by MR
no carotid thermal heterogeneity
Patients that DONT have carotid thermal heterogeneity detected by MR
carotid artery disease
Patients with detected carotid artery disease by ultrasound
no carotid artery disease
Patients with no carotid artery disease detected by ultrasound

Detailed Description:
Carotid artery Thermal heterogeneity recorded by MR will be corelated to cardiovascular events (death, cardiac events, cerebrovascular events) as well as to all demographic (age, sex, hypertension, dyslipidemia, smoking status, etc) factors

Ages Eligible for Study:   30 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with coronary artery disease

Inclusion Criteria:

  • Consecutive patients with coronary artery disease admitted in our hospital

Exclusion Criteria:

  • Patients with history of previous cerebrovascular event,
  • History of vasculitis, intermittent inflammatory, infectious, or neoplastic conditions likely to be associated with an acute-phase response.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01521351

Contact: Konstantinos Toutouzas
Contact: Andreas Synetos

First Department of Cardiology, University of Athens, Medical School. Hippocratio Hospital Recruiting
Athens, Attiki, Greece, 11528
Contact: Andreas Synetos, MD    00306945417784   
Sub-Investigator: Andreas Synetos, MD         
Sponsors and Collaborators
University of Athens
Principal Investigator: Konstantinos Toutouzas First department of Cardiology, University of Athens Greece
  More Information

Additional Information:
Responsible Party: Konstantinos Toutouzas, Associate Professor of Cardiology, University of Athens Identifier: NCT01521351     History of Changes
Other Study ID Numbers: MRcar
Study First Received: January 25, 2012
Last Updated: May 26, 2015

Keywords provided by University of Athens:
microwave radiometry
cardiovascular events
carotid artery disease
myocardial infarction

Additional relevant MeSH terms:
Carotid Artery Diseases
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases
Nervous System Diseases
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Myocardial Infarction
Angina Pectoris
Pathologic Processes
Myocardial Ischemia
Chest Pain
Neurologic Manifestations
Signs and Symptoms processed this record on May 22, 2017