This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Cognitive Training for Patients With Schizophrenia

This study has been completed.
National Alliance for Research on Schizophrenia and Depression
Information provided by (Responsible Party):
ETwamley, University of California, San Diego Identifier:
First received: January 22, 2012
Last updated: November 15, 2013
Last verified: November 2013

This research on cognitive training addresses the following questions:

  1. Does cognitive training lead to improved cognition, functional abilities, psychiatric symptoms, treatment adherence, or quality of life in patients with psychoses?
  2. What are the neurocognitive and non-cognitive factors that predict good outcomes following cognitive rehabilitation? In addition to verbal learning and memory, immediate verbal memory, vigilance, and executive functioning, the cognitive training intervention attempted to improve prospective memory ability (i.e., the ability to remember to do things in the future, such as take medications or attend a doctor's appointment).

Condition Intervention Phase
Schizophrenia Schizoaffective Disorder Other Primary Psychotic Disorders Behavioral: Cognitive Training Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Cognitive Training for Patients With Schizophrenia

Resource links provided by NLM:

Further study details as provided by ETwamley, University of California, San Diego:

Primary Outcome Measures:
  • UCSD Performance-based Skills Assessment Total Score (Measures Functional Capacity) [ Time Frame: 3 months ]
    Performance-based measure of functional capacity in five domains: Communication, Finance, Recreation Planning, Transportation, and Household Chores Scale ranges from 0-100. Subscales are summed to yield the total score. Higher scores represent better performance.

Secondary Outcome Measures:
  • Hopkins Verbal Learning Test Percent Retained [ Time Frame: 3 months ]

    Verbal list learning task with three learning trials and a delay trial. Percent retained refers to the percentage of items recalled at the delay trial, compared to the third learning trial.

    Score ranges from 0-100. Higher scores represent better performance.

Enrollment: 69
Study Start Date: September 2003
Study Completion Date: August 2009
Primary Completion Date: August 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Cognitive Training
Cognitive training group
Behavioral: Cognitive Training
12-week compensatory cognitive training in group format
No Intervention: Standard Pharmacotherapy


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Primary psychotic disorder (including schizophrenia, schizoaffective disorder, psychotic mood disorder, or psychosis NOS)
  • Age 18 or older
  • Fluency in English

Exclusion Criteria:

  • Dementia
  • Neurological conditions affecting cognition
  • Mental retardation
  • Substance use disorder within the past month
  • Participation in other intervention trials
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01521026

United States, California
UCSD Outpatient Psychiatric Services
San Diego, California, United States, 92103
Sponsors and Collaborators
University of California, San Diego
National Alliance for Research on Schizophrenia and Depression
Principal Investigator: Elizabeth W Twamley, PhD UCSD
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: ETwamley, Associate Professor of Psychiatry, University of California, San Diego Identifier: NCT01521026     History of Changes
Other Study ID Numbers: NARSAD Young Investigator
Study First Received: January 22, 2012
Results First Received: July 1, 2013
Last Updated: November 15, 2013

Additional relevant MeSH terms:
Psychotic Disorders
Mental Disorders
Pathologic Processes
Schizophrenia Spectrum and Other Psychotic Disorders processed this record on August 16, 2017