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Gene Expression in Samples From Patients With T-Cell Acute Lymphoblastic Leukemia

This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Children's Oncology Group Identifier:
First received: January 26, 2012
Last updated: July 7, 2016
Last verified: July 2016

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

PURPOSE: This research trial studies gene expression in samples from patients with T-cell acute lymphoblastic leukemia.

Condition Intervention
Leukemia Lymphoma Genetic: gene expression analysis Other: laboratory biomarker analysis

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Signaling in Tumorigenesis and Immunity

Resource links provided by NLM:

Further study details as provided by Children's Oncology Group:

Primary Outcome Measures:
  • PDLIM2 expression patterns in cancer and control tissues
  • 8-week survival of human T-cell co-cultured with HTLV-1-transformed T-cell lines

Biospecimen Retention:   Samples With DNA
tissue, blood, and bodily fluids

Estimated Enrollment: 20
Study Start Date: January 2012
Primary Completion Date: July 2016 (Final data collection date for primary outcome measure)
Detailed Description:


  • To test whether the tumor suppressor candidate gene PDLIM2 is downregulated in human cancers such as T-cell acute lymphoblastic leukemia (T-ALL) and to use the human T-lymphotropic virus 1 (HTLV-1)-mediated in vitro transformation of human T cells as control.

OUTLINE: Previously collected cancer and control tissues are analyzed for the expression patterns of PDLIM2 and other control genes. Human T-cells isolated from human blood are also co-cultured with HTLV-1-transformed T-cell lines.


Ages Eligible for Study:   up to 120 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients With T-Cell Acute Lymphoblastic Leukemia


  • Specimens (e.g., tissue, blood, and bodily fluids) of various cancer cells and or tissues from de-identified patients such as T-cell acute lymphoblastic leukemia (T-ALL)
  • Normal control tissue


  • Not specified


  • Not specified
  Contacts and Locations
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Please refer to this study by its identifier: NCT01520246

Sponsors and Collaborators
Children's Oncology Group
National Cancer Institute (NCI)
Principal Investigator: Gutian Xiao, MD University of Pittsburgh
  More Information

Responsible Party: Children's Oncology Group Identifier: NCT01520246     History of Changes
Other Study ID Numbers: AALL12B2
COG-AALL12B2 ( Other Identifier: Children's Oncology Group )
CDR0000723902 ( Other Identifier: )
AALL12B2 ( Other Identifier: COG )
NCI-2012-00241 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
Study First Received: January 26, 2012
Last Updated: July 7, 2016

Keywords provided by Children's Oncology Group:
adult acute lymphoblastic leukemia
childhood acute lymphoblastic leukemia
adult T-cell leukemia/lymphoma

Additional relevant MeSH terms:
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases processed this record on August 18, 2017