CYP3A4 Metabolism Before and After Surgery Induced Weight Loss Using Midazolam as Model Drug (MEMO)
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ClinicalTrials.gov Identifier: NCT01519726
Verified January 2012 by Catherijne Knibbe, St. Antonius Hospital. Recruitment status was: Recruiting
Before and during bariatric surgery patients are given oral and i.v. midazolam, respectively and blood samples are drawn to establish midazolam time-concentration profiles. After 0.5-2 years, and substantial weight loss, oral and i.v. midazolam are administered once more and blood samples are taken again.
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Ages Eligible for Study:
18 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
undergoing bariatric surgery
use of drug inducing or inhibiting CYP3A4 activity