Preeclampsia: A Marker for Future Cardiovascular Risk in Women
This study will compare blood vessel and hormone differences between women who have a history of a pregnancy complicated by preeclampsia or high blood pressure, and women who have a history of uncomplicated pregnancy in the last 10 years. The investigators hypothesize that postpartum women with history of preeclampsia will have altered blood vessel function and abnormal hormone levels compared with postpartum women with history of uncomplicated pregnancy.
This study will take place over the course of 2 weeks. Each subject will be assessed on a fixed low-salt diet and a fixed high-salt diet. Subjects will have 2 non-invasive blood vessel imaging tests and fasting blood draws.
|Study Design:||Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Screening
|Official Title:||Preeclampsia: A Marker for Future Cardiovascular Risk in Women|
- Vascular function [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]Assess vascular function after administration of an angiotensin receptor blocker.
- Hormonal measurements [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]Assess hormone levels pertaining to the renin-angiotensin system after administration of irbesartan.
|Study Start Date:||May 2012|
|Estimated Study Completion Date:||September 2016|
|Estimated Primary Completion Date:||September 2016 (Final data collection date for primary outcome measure)|
Single arm intervention
Irbesartan 150 mg orally for one dose
150mg orally for one dose
Please refer to this study by its ClinicalTrials.gov identifier: NCT01519297
|Contact: Ellen W Seely, MD||617-732-8538|
|United States, Massachusetts|
|Brigham and Women's Hospital||Recruiting|
|Boston, Massachusetts, United States, 02115|
|Principal Investigator:||Ellen W Seely, MD||Brigham and Women's Hospital|