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Antro-pyloro-duodenal Motility in Idiopathic Gastroparesis

This study has been completed.
Information provided by (Responsible Party):
University Hospital, Rouen Identifier:
First received: January 18, 2012
Last updated: September 5, 2014
Last verified: September 2014
Impaired gastric emptying may cause dyspeptic symptoms including nausea, vomiting and even nutritionnal impairment. Delay in gastric emptying may result from antro-pyloro-duodenal motility impairement.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study of the Antro-pyloro-duodenal Motor Dysfunction in Idiopathic Gastroparesis

Further study details as provided by University Hospital, Rouen:

Primary Outcome Measures:
  • antro-pyloro-duodenal pressure [ Time Frame: 3h ]
    the main outcome is the pressure measured using pressure sensors within the antrum, the pylorus, and the first part of the duodenum. This will be measured during 3h fast. Pressures measured in the antrum, the pylorus, and the duodenum wiil be compared between healthy volunteers and gastroparetic patients

Enrollment: 32
Study Start Date: January 2012
Study Completion Date: January 2014
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Control group
Healthy volunteers
Idiopathic gastroparesis
Idiopathic gastroparesis

Detailed Description:
The aim of this study is therefore to measure antro-pyloro-duodenal motor activity in patients with idiopathic gastroparesis.

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Idiopathic gastroparesis and healthy volunteers

Inclusion Criteria:

  • Idiopathic gastroparesis or healthy volunteers
  • Idiopathic gastroparesis must have delayed gastric emptying shown using C13 breath test

Exclusion Criteria:

  • Diabetic or post-surgical gastroparesis
  • Treatment modifying GI motility (prokinetics, opioids...)
  • Parkinson or neurologic disease
  • Evoluting inflammatory process or neoplasia
  • Treatment modifying coagulation
  • Patients not affiliated to the French healthcare insurance
  Contacts and Locations
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Please refer to this study by its identifier: NCT01519180

Service de Physiologie
Rouen, Haute normandie, France, 76000
Sponsors and Collaborators
University Hospital, Rouen
Principal Investigator: Guillaume Gourcerol, MD, PhD Chu de rouen
  More Information

Responsible Party: University Hospital, Rouen Identifier: NCT01519180     History of Changes
Other Study ID Numbers: 2010/148/HP
Study First Received: January 18, 2012
Last Updated: September 5, 2014

Keywords provided by University Hospital, Rouen:
gastric emptying
antro-duodenal manometry

Additional relevant MeSH terms:
Stomach Diseases
Gastrointestinal Diseases
Digestive System Diseases
Neurologic Manifestations
Signs and Symptoms processed this record on September 21, 2017