Reducing Radioisotope Dose: the Half-Dose CZT Study
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|ClinicalTrials.gov Identifier: NCT01518777|
Recruitment Status : Recruiting
First Posted : January 26, 2012
Last Update Posted : February 9, 2017
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease||Other: Half-dose isotope for NuclearStressTest||Not Applicable|
The aim of this study is to compare the image quality of the half radioisotope dose scans obtained using a CZT (cadmium zinc telluride) camera with scans acquired using a standard of care imaging protocol/radioisotope dose performed on a traditional (conventional) camera.
The proposed strategy of a half dose/extended time protocol with the CZT camera should yield a similar count activity and consequently image quality equivalent to that detected by a conventional SPECT system.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Reducing Radioisotope Dose in Regadenoson SPECT Myocardial Perfusion Imaging: Comparison of Half-Dose Scans Using a Novel Solid-State-Detector Dedicated Cardiac Camera to Full Dose Scans Acquired On Standard Equipment|
|Study Start Date :||January 2012|
|Estimated Primary Completion Date :||November 2017|
|Estimated Study Completion Date :||November 2017|
Half-dose isotope for NuclearStressTest
Intervention is Nuclear stress test of the heart. Single-arm of this study "Half-dose of isotope for Nuclear stress test" is group of study subjects who will do Research Nuclear stress test with half-dose of isotope that normally used for routine Nuclear stress test. Isotope is the tracer CZT (cadmium zinc telluride) that used for Nuclear stress test routinely to see the function of arteries of the heart. Patients with suspected Coronary Artery Disease who meet entry criteria undergo a research nuclear stress test using a decreased dose of isotope, using a new camera.
Other: Half-dose isotope for NuclearStressTest
Half-dose of tracer or radioisotope will be used for Nuclear stress test of the heart. This is imaging test of the heart to see the function of arteries of the heart.
Other Name: SPECT using CZT
- Image quality of the half-dose CZT versus full dose scans [ Time Frame: 1 Week ]
- Total radiation dose/exposure of the half-dose CZT vs. full dose scans [ Time Frame: 1 Week ]
- Total myocardial count activity and count rates obtained during each scan [ Time Frame: 1 Week ]
- Agreement between the half-dose CZT vs. full dose scans on the presence and extent of fixed or reversible defects on a per-patient and vessel basis [ Time Frame: 1 Week ]
- Agreement between the half-dose vs. full dose scans on gated data such as EF, left ventricular (LV) end-diastolic volume, LV end-systolic volume [ Time Frame: 1 Week ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01518777
|Contact: Christopher Mattairfirstname.lastname@example.org|
|United States, Texas|
|Houston Methodist Hospital||Recruiting|
|Houston, Texas, United States, 77030|
|Contact: Christopher Mattair 713-363-9956 email@example.com|
|Principal Investigator: Su Min Chang, MD|
|Sub-Investigator: Faisal Nabi, MD|
|Sub-Investigator: Mahmarian John, MD|
|Principal Investigator:||Su Min Chang, MD||The Methodist Hospital System|