Alfentanil and the Elimination of Sympathetic Responses to Tracheal Intubation During Rapid Sequence Induction of Anesthesia: A Probability-based Approach
Induction of anesthesia:
After 3 minutes pre-oxygenation with 100% oxygen, a blinded dose alfentanil (0,10,20,30,40,50 or 60 µg/kg, followed by thiopental 4 mg/kg and rocuronium 0.6 mg/kg will be administered over 15 sec. Laryngoscopy will be performed 40 s. after injection of rocuronium, with the goal being to have the endotracheal tube passed through the patients vocal cords and the cuff inflated within the following 15 s . The investigator performing the tracheal intubation is blinded to the dose of alfentanil administered.
As part of the study efficacy, blood samples, will be collected prior to induction and 30 s., 1 min. 3 min. and 5 min postintubation to determine blood concentrations of alfentanil and catecholamines.
|Anesthesia Intubation Complication||Drug: Alfentanil 0.5mg/ml (Rapifen , Janssen-Cilag)||Phase 4|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Prevention
|Official Title:||Alfentanil and the Elimination of Sympathetic Responses to Tracheal Intubation During Rapid Sequence Induction of Anesthesia: A Probability-based Approach|
- Alfentanil and blockage of sympathetic responses: A dose-response study. [ Time Frame: 2 years ]Effectivness of controling Blood pressure during intubation
|Study Start Date:||September 2009|
|Study Completion Date:||October 2011|
|Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
Drug: Alfentanil 0.5mg/ml (Rapifen , Janssen-Cilag)
Induction dose(0µg/kg,10µg/kg,20µg/kg,30µg/kg,40µg/kg,50µg/Kg,and 60µg/kg) 12 patients in each dose group.
Pentothal 4mg/kg Rocuronium 0.6 mg/kg
Please refer to this study by its ClinicalTrials.gov identifier: NCT01518608
|Oslo University Hospital/ Aker|
|Oslo, Akershus, Norway, 0514|
|Oslo University Hospital / Aker|
|Oslo, Norway, 0514|
|Study Director:||Tom Heier, MD, Phd.||University of Oslo|