Acceptance and Commitment Therapy Versus Cognitive Therapy for the Treatment of Major Depressive Disorder
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ClinicalTrials.gov Identifier: NCT01517503 |
Recruitment Status :
Completed
First Posted : January 25, 2012
Last Update Posted : July 30, 2019
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Major Depressive Disorder | Behavioral: Cognitive Therapy Behavioral: Acceptance and Commitment Therapy | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 82 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Acceptance and Commitment Therapy vs. Cognitive Therapy for the Treatment of Major Depressive Disorder |
Study Start Date : | December 2011 |
Actual Primary Completion Date : | August 2015 |
Actual Study Completion Date : | August 2015 |

Arm | Intervention/treatment |
---|---|
Experimental: Cognitive Therapy (CT)
Cognitive Therapy (CT)
|
Behavioral: Cognitive Therapy
This interventions will target: (a) behavioral dysfunction, (b) situation-specific negative thinking and cognitive distortions, and (c) underlying dysfunctional beliefs or cognitions assumed to be related to the patient's current depression and risk of future depression. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
Other Name: Cognitive behavior therapy; cognitive behaviour therapy. |
Experimental: Acceptance and Commitment Therapy (ACT)
Acceptance and Commitment Therapy (ACT)
|
Behavioral: Acceptance and Commitment Therapy
This interventions will use (a) acceptance, (b) commitment, (c) mindfulness, and (d) behavior change processes to produce reduction of depressive symptoms. A maximum of 20 45-55 minute sessions will be provided, with sessions generally held weekly for the first 8 sessions and once every two weeks for the next 8 sessions.
Other Name: Mindfulness-based interventions |
- QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR) [ Time Frame: pre-treatment, post-treatment, 6 and 12 months follow-up ]Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up
- Hamilton Rating Scale for Depression [ Time Frame: pre-treatment, post-treatment ]Change from pre-treatment to post-treatment.
- Decentering subscale of the Experiences Questionnaire [ Time Frame: Pre-treatment, in-treatment, and 6 and 12 months follow-up. ]Change between sessions and to follow-up.
- Acceptance and Action Questionnaire [ Time Frame: Pre-treatment, in-treatment, and 6 and 12 months follow-up. ]Change between sessions and to follow-up.
- Dysfunctional Attitude Scale-revised [ Time Frame: Pre-treatment, in-treatment, and 6 and 12 months follow-up ]Change between sessions to follow-up.
- Working Alliance Inventory [ Time Frame: 3. session ]
- Eurohis Quality of Life Scale [ Time Frame: Pre-, post-treatment, 6 and 12 months follow-up ]Change pre-treatment to post-treatment and to follow-up.
- Relationship Scales [ Time Frame: Pre-, post-treatment, 12 months follow-up ]Change pre-treatment to post-treatment and to follow-up.
- Implicit Attitude Test [ Time Frame: Pre- and posttreatment ]Change pre-treatment to post-treatment
- Structured Clinical Interview for DSM-IV (Major Depression Module) [ Time Frame: Pre-treatment and post-treatment. ]Change in diagnosis of Major Depression Disorder from pre-treatment to post-treatment.

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Meeting DSM-IV criteria for MDD
- Between the ages of 18 and 65-years-old
- Having sufficient fluency in Dutch to complete treatment and research protocol
Exclusion Criteria:
- DSM-IV criteria for bipolar disorder (past or present)
- Psychotic disorders
- Substance dependence disorders (current or within the past 6 months), or
- Organic brain syndrome.
- Borderline or antisocial personality disorder

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01517503
Netherlands | |
PsyQ | |
Zaandam, Netherlands, 1500 AE |
Principal Investigator: | Paul MG Emmelkamp, PhD | University of Amsterdam | |
Study Director: | Nexhmedin Morina, PhD | University of Amsterdam |
Responsible Party: | Paul M.G.Emmelkamp, Professor, VU University of Amsterdam |
ClinicalTrials.gov Identifier: | NCT01517503 |
Other Study ID Numbers: |
METC 10/103 |
First Posted: | January 25, 2012 Key Record Dates |
Last Update Posted: | July 30, 2019 |
Last Verified: | July 2019 |
Depressive Disorder Depression Depressive Disorder, Major |
Mood Disorders Mental Disorders Behavioral Symptoms |