Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing
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The purpose of this research study is to screen healthy African American and Caucasian persons for specific differences in genes that control how fats are processed in the body.
Condition or disease
Healthy African American and Caucasian persons will be screened for specific differences in genes that control how fats are processed in the body. Persons with the needed genotypes will be added to a database of healthy persons who may be asked to join a larger study comparing differences in diet on lipid metabolism and inflammatory biomarkers as well as future studies. A key hypothesis for the larger study is that variations in genes involved in lipid metabolism play a role in determining levels of long chain polyunsaturated fatty acids (LC-PUFAs).
Determine the genotype at the rs174537 single-nucleotide polymorphism (SNP) in the fatty acid desaturate (FADS) gene cluster [ Time Frame: up to 52 months ]
Biospecimen Retention: Samples With DNA
A small saliva sample for screening purposes will be collected. If documentation from a personal physician of blood glucose and lipid levels are unavailable, we will collect a small tube (10-12 ml) of blood to determine these measurements.
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Ages Eligible for Study:
21 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Caucasian or African American adults between 21 and 65 years of age
Be Caucasian or African American between 21-65 years of age
Be healthy and free of any major illness
Be a nonsmoker
Have an intact gallbladder
Have TG < 150 and blood pressure less than 130/90
Must be willing to be re-contacted for future studies
Not have: myocardial infarction, vascular surgery or stroke within the past year
Not be taking niacin, more than 100 mg aspirin/day or montelukast allergy medications