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How Fat Influences the Brain

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ClinicalTrials.gov Identifier: NCT01516021
Recruitment Status : Completed
First Posted : January 24, 2012
Last Update Posted : January 24, 2012
Sponsor:
Collaborators:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The aim of the current study was to investigate the effect of a high versus a low fat meal (operationalized by high and low fat yoghurt) on homeostatic and gustatory brain regions.

Condition or disease Intervention/treatment
Fat Processing in the Brain Dietary Supplement: intake of high or low fat yoghurt

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 11 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Fat Intake Modulates Cerebral Blood Flow in Homeostatic and Gustatory Brain Areas in Humans
Study Start Date : January 2011
Primary Completion Date : March 2011
Study Completion Date : March 2011
Arms and Interventions

Arm Intervention/treatment
Experimental: high fat yoghurt intake
500 ml of a high fat yoghurt
Dietary Supplement: intake of high or low fat yoghurt
intake of 500 ml of a high fat yoghurt on one day and intake of 500 ml of a low fat yoghurt on the other day
Experimental: low fat yoghurt intake Dietary Supplement: intake of high or low fat yoghurt
intake of 500 ml of a high fat yoghurt on one day and intake of 500 ml of a low fat yoghurt on the other day


Outcome Measures

Primary Outcome Measures :
  1. Changes in Cerebral Blood Flow due to the high or low fat yoghurt intake after 30 minutes and 120 minutes compared to a baseline measurement 30 minutes before yoghurt intake. [ Time Frame: 30 minutes before as well as 30 minutes and 120 minutes after fat intake ]

    We were interested in differential brain activations due to the high or low fat meal. To assess this, the mentioned time points are suitable.

    The Cerebral Blood Flow is measured using Arterial Spin Labeling sequences in a functional magnetic resonance tomography.



Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   25 Years to 32 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • male
  • healthy

Exclusion Criteria:

  • lactose intolerance
  • fMRI contraindications (metal implants,...)
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01516021


Locations
Germany
University Clinic of Tuebingen, MEG Center
Tuebingen, Germany, 72076
Sponsors and Collaborators
University Hospital Tuebingen
German Research Foundation
German Federation of Industrial Research Associations
Zentrum für Ernährungsmedizin und Prävention
German Center for Diabetes Research
University of Hohenheim
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Sabine Frank, Principal Investigator, University Hospital Tuebingen
ClinicalTrials.gov Identifier: NCT01516021     History of Changes
Other Study ID Numbers: YOG
First Posted: January 24, 2012    Key Record Dates
Last Update Posted: January 24, 2012
Last Verified: January 2012

Keywords provided by Sabine Frank, University Hospital Tuebingen:
Fat ingestion
hypothalamus
insula
fMRI
CBF