Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease

This study is ongoing, but not recruiting participants.
Medical Research Council
Information provided by (Responsible Party):
Royal Brompton & Harefield NHS Foundation Trust Identifier:
First received: January 10, 2012
Last updated: November 4, 2014
Last verified: November 2014

Patients with Chronic Obstructive Lung Disease (COPD) often develop muscle problems, particularly in their legs which makes them more limited in what they can do. The Short Physical Performance Battery (SPPB) is a simple test of standing balance, usual walking speed and ability to stand from a chair. The SPPB may be a useful measure to predict leg function.

This study aims to evaluate whether the SPPB is comparable with current exercise tests used in COPD patients, and whether it is useful in predicting disability, death and health resource usage over time.

Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Pulmonary Emphysema
Bronchitis, Chronic
Lung Diseases
Disease Progression

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Is the Short Physical Performance Battery a Useful Outcome Measure in Patients With Chronic Obstructive Pulmonary Disease ?

Resource links provided by NLM:

Further study details as provided by Royal Brompton & Harefield NHS Foundation Trust:

Primary Outcome Measures:
  • Mortality rate [ Time Frame: 36 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Hospitalisation rate [ Time Frame: 36 months ] [ Designated as safety issue: No ]
  • Healthcare resource usage [ Time Frame: 36 months ] [ Designated as safety issue: No ]

Enrollment: 445
Study Start Date: April 2011
Estimated Study Completion Date: September 2016
Primary Completion Date: September 2013 (Final data collection date for primary outcome measure)
Chronic Obstructive Pulmonary Disease
Patients with a diagnosis of COPD


Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Any patient with a diagnosis of COPD.

Inclusion Criteria:

  • Diagnosis of COPD

Exclusion Criteria:

  • Any patient in whom mobility and lower limb function have been significantly affected by a neuromuscular cause (eg. motor neurone disease), severe peripheral vascular disease or amputation
  • Any patient whom is deemed unsafe to exercise
  • Patients unable to complete the SPPB, walking tests and leg strength assessments.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01515709

United Kingdom
Harefield Hospital
Harefield, United Kingdom, UB9 6JH
Sponsors and Collaborators
Royal Brompton & Harefield NHS Foundation Trust
Medical Research Council
Principal Investigator: William DC Man, MRCP PhD NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust
  More Information

Responsible Party: Royal Brompton & Harefield NHS Foundation Trust Identifier: NCT01515709     History of Changes
Other Study ID Numbers: 2011LF001H 
Study First Received: January 10, 2012
Last Updated: November 4, 2014
Health Authority: United Kingdom: Research Ethics Committee
United Kingdom: National Institute for Health Research
United Kingdom: National Health Service

Keywords provided by Royal Brompton & Harefield NHS Foundation Trust:
Cohort Studies
Longitudinal Studies

Additional relevant MeSH terms:
Chronic Disease
Disease Progression
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Pulmonary Emphysema
Bronchial Diseases
Disease Attributes
Respiratory Tract Diseases
Bronchitis, Chronic
Pathologic Processes
Respiratory Tract Infections processed this record on May 26, 2016