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Is the Short Physical Performance Battery a Useful Outcome Measure in Chronic Obstructive Pulmonary Disease

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ClinicalTrials.gov Identifier: NCT01515709
Recruitment Status : Active, not recruiting
First Posted : January 24, 2012
Last Update Posted : May 12, 2017
Medical Research Council
Information provided by (Responsible Party):
Royal Brompton & Harefield NHS Foundation Trust

Brief Summary:

Patients with Chronic Obstructive Lung Disease (COPD) often develop muscle problems, particularly in their legs which makes them more limited in what they can do. The Short Physical Performance Battery (SPPB) is a simple test of standing balance, usual walking speed and ability to stand from a chair. The SPPB may be a useful measure to predict leg function.

This study aims to evaluate whether the SPPB is comparable with current exercise tests used in COPD patients, and whether it is useful in predicting disability, death and health resource usage over time.

Condition or disease
Pulmonary Disease, Chronic Obstructive Lung Diseases, Obstructive Pulmonary Emphysema Bronchitis, Chronic Lung Diseases Disease Progression

Study Type : Observational
Actual Enrollment : 445 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Is the Short Physical Performance Battery a Useful Outcome Measure in Patients With Chronic Obstructive Pulmonary Disease ?
Actual Study Start Date : April 2011
Primary Completion Date : September 2013
Estimated Study Completion Date : September 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases
U.S. FDA Resources

Chronic Obstructive Pulmonary Disease
Patients with a diagnosis of COPD

Primary Outcome Measures :
  1. Mortality rate [ Time Frame: 36 months ]

Secondary Outcome Measures :
  1. Hospitalisation rate [ Time Frame: 36 months ]
  2. Healthcare resource usage [ Time Frame: 36 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Any patient with a diagnosis of COPD.

Inclusion Criteria:

  • Diagnosis of COPD

Exclusion Criteria:

  • Any patient in whom mobility and lower limb function have been significantly affected by a neuromuscular cause (eg. motor neurone disease), severe peripheral vascular disease or amputation
  • Any patient whom is deemed unsafe to exercise
  • Patients unable to complete the SPPB, walking tests and leg strength assessments.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01515709

United Kingdom
Harefield Hospital
Harefield, United Kingdom, UB9 6JH
Sponsors and Collaborators
Royal Brompton & Harefield NHS Foundation Trust
Medical Research Council
Principal Investigator: William DC Man, MRCP PhD NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Royal Brompton & Harefield NHS Foundation Trust
ClinicalTrials.gov Identifier: NCT01515709     History of Changes
Other Study ID Numbers: 2011LF001H
First Posted: January 24, 2012    Key Record Dates
Last Update Posted: May 12, 2017
Last Verified: May 2017

Keywords provided by Royal Brompton & Harefield NHS Foundation Trust:
Cohort Studies
Longitudinal Studies

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Chronic Disease
Disease Progression
Pulmonary Emphysema
Bronchitis, Chronic
Respiratory Tract Diseases
Disease Attributes
Pathologic Processes
Bronchial Diseases
Respiratory Tract Infections