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A MRI Study of Visual and Motor Pathways in Premature Infants

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Arkansas Children's Hospital Research Institute Identifier:
First received: January 18, 2012
Last updated: March 10, 2017
Last verified: March 2017
Approximately 30,000 babies annually are born with extremely low birth weight (ELBW) in the US. These babies often have motor and/or visual problems when they grow up. It is very important to identify high risk ELBW infants as early as possible, so that the investigators can treat them earlier to prevent poor development. Neurological examination at early age is not good enough to identify high risk ELBW infants. One the other hand, some magnetic resonance imaging (MRI) methods such as diffusion tensor imaging (DTI) and resting state functional MRI (rfMRI) have shown great sensitivity to brain injury which may cause motor and visual problems. Therefore, the investigators propose to use DTI and rfMRI on ELBW infants at a very early age to predict long−term outcome and to identify infants who are at high risk of having motor and/or visual problems when they grow up.

Premature Birth

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Further study details as provided by Arkansas Children's Hospital Research Institute:

Primary Outcome Measures:
  • MRI [ Time Frame: 0 ]

Estimated Enrollment: 40
Study Start Date: October 2011
Estimated Study Completion Date: August 2018
Estimated Primary Completion Date: August 2018 (Final data collection date for primary outcome measure)
ELBW infants


Ages Eligible for Study:   2 Months to 5 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
ELBW infants with birth weight 401-1000 g (gestational age <30 weeks)

Inclusion Criteria:

  • ELBW infants with birth weight 401-1000 g (gestational age <30 weeks)

Exclusion Criteria:

  • Complex congenital anomalies
  • Central nervous system malformations,
  • Chromosomal abnormalities, or hydrops fetalis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01514747

United States, Arkansas
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72211
Sponsors and Collaborators
Arkansas Children's Hospital Research Institute
  More Information

Responsible Party: Arkansas Children's Hospital Research Institute Identifier: NCT01514747     History of Changes
Other Study ID Numbers: ISMRM_OU
ISMRM_2011 ( Other Grant/Funding Number: ISMRM Seed Grant )
Study First Received: January 18, 2012
Last Updated: March 10, 2017

Additional relevant MeSH terms:
Premature Birth
Obstetric Labor, Premature
Obstetric Labor Complications
Pregnancy Complications processed this record on May 25, 2017