Thromboelastography in Non-elective Cesarean Delivery
The purpose of the study is to assess the coagulation changes that occur in laboring patients undergoing non-elective (intrapartum)Cesarean delivery using thromboelastography (TEG). We will compare coagulation data to assess potential coagulation changes associated with hemoglobin changes before and after surgery, and related to estimated blood loss.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Thromboelastography to Assess Hemostatic Changes in Laboring Patients Undergoing Non-elective (Intrapartum) Cesarean Delivery|
- Estimated blood loss; Coagulation data (Thromboelastography, Laboratory) [ Time Frame: pre and post cesarean delivery, an expected average of 75 minutes ] [ Designated as safety issue: No ]This study will allow us to collect more information about the hemostatic effects that occur during non-elective Cesarean delivery. This information will add to current knowledge base (which we have published) about coagulation changes in the peripartum period in patients undergoing non-elective Cesarean section.
- Hematologic indices [ Time Frame: Pre and post cesarean delivery, an expected average of 75 minutes ] [ Designated as safety issue: No ]Hematologic indices will include: Hemoglobin concentration and platelet count.
Biospecimen Retention: Samples With DNA
Blood samples for TEG analysis.
|Study Start Date:||August 2011|
|Study Completion Date:||June 2013|
|Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Non-elective Cesarean Delivery
We will only enroll patients undergoing non-elective CS with an 'epidural top-up' for surgical anesthesia. By definition, our study will only apply to laboring women with working labor epidurals (which were provided for labor analgesia).
The purpose of the study is to assess the coagulation changes that occur in laboring patients undergoing non-elective (intrapartum)Cesarean delivery using thromboelastography (TEG). TEG is a point- of-care device which measures the viscoelastic properties of clot formation. This device can provide rapid and detailed information about coagulation changes in the perioperative period. We will compare coagulation data collected from the study to assess potential coagulation changes associated with Hemoglobin changes before and after surgery, and related to estimated blood loss.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01514591
|United States, California|
|Lucile Packard Children's Hospital|
|Stanford, California, United States, 94305|
|Principal Investigator:||Alex Butwick, MBBS, FRCA||Stanford University|