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Alternative Treatments of Vitamin D Deficiency

This study has been completed.
Information provided by (Responsible Party):
Morten Bogh, Lund University Identifier:
First received: December 22, 2011
Last updated: January 15, 2012
Last verified: January 2012
The purpose of the study is to compare the efficiency of UVB and vitamin D supplementation in treatment of vitamin D deficiency.

Condition Intervention
Vitamin D Deficiency
Radiation: Narrowband UVB
Dietary Supplement: Vitamin D and calcium

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Comparison of UVB and Vitamin D Supplementation in Treatment of Vitamin D Deficiency

Resource links provided by NLM:

Further study details as provided by Lund University:

Primary Outcome Measures:
  • Vitamin D (nmol/l). [ Time Frame: Week 0 ]
    Vitamin D was measured in a bloodsample to determine baseline status.

  • Vitamin D (nmol/l) [ Time Frame: Week 3 ]
    Vitamin D was measured in a bloodsample to follow the change from baseline in vitamin D level at week 3.

  • Vitamin D [ Time Frame: Week 6 ]
    Vitamin D was measured in a bloodsample to follow the change from baseline in vitamin D level at week 6.

Secondary Outcome Measures:
  • Parathyroid hormone (pmol/l). [ Time Frame: Week 0, 3 and 6. ]
    To investigate whether parathyrodiea hormone changes during the study.

  • Albumin (g/l). [ Time Frame: Week 0, 3 and 6. ]
    To investigate whether albumin changes during the study.

  • Calcium (mmol/l) [ Time Frame: Week 0, 3 and 6. ]
    To investigate whether calcium changes during the study.

  • Hemoglobin A 1c (percentage HbA1c of total hemoglobin). [ Time Frame: Week 0, 3 and 6. ]
    To investigate whether HbA1c changes during the study.

Enrollment: 32
Study Start Date: February 2010
Study Completion Date: November 2011
Primary Completion Date: April 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: UVB
UVB exposed group
Radiation: Narrowband UVB
UVB 3 times a week
Other Name: NB-UVB
Active Comparator: Oral vitamin D tablet
Vitamin D supplementation
Dietary Supplement: Vitamin D and calcium
1 daily tablet of 1600 IU vitamin D3 and 1000 mg calcium
Other Name: Vitamin D supplementation

Detailed Description:
Patients with vitamin D deficiency were recruited and randomized into two groups, one exposed to UVB and the other receiving oral treatment with vitamin D supplementation.

Ages Eligible for Study:   15 Years to 70 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Vitamin D deficiency (< 25 nmol/l)
  • Age 15 or above

Exclusion Criteria:

  • Travel south of 45 degrees latitude during the trial.
  • Ongoing treatment with vitamin D supplementation.
  • Intake of light sensitive medicine, such as tetracyclins.
  • Skin light eruptions
  Contacts and Locations
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Please refer to this study by its identifier: NCT01512537

Department of Dermatology, Lund University Malmoe
Malmoe, Sweden, 205 02
Sponsors and Collaborators
Lund University
Study Chair: Åke Svensson, Assoc. Prof., MD, PhD Department of Dermatology, Lund University, Malmoe
  More Information

Responsible Party: Morten Bogh, Principal Investigator, Lund University Identifier: NCT01512537     History of Changes
Other Study ID Numbers: 2009/687
Study First Received: December 22, 2011
Last Updated: January 15, 2012

Keywords provided by Lund University:
Vitamin D
Vitamin D supplementation

Additional relevant MeSH terms:
Vitamin D Deficiency
Deficiency Diseases
Nutrition Disorders
Vitamin D
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on May 25, 2017