Brain-imaging and Adolescent Neuroscience Consortium (BANC)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01511679
Recruitment Status : Withdrawn (The project was not funded.)
First Posted : January 19, 2012
Last Update Posted : January 3, 2013
Massachusetts General Hospital
Mclean Hospital
Massachusetts Institute of Technology
Information provided by (Responsible Party):
Boston Children’s Hospital

Brief Summary:
This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.

Condition or disease
Alcohol Abuse

Detailed Description:
The overall specific aims of this study are to: 1) assess the short and long-term consequences of alcohol exposure on brain, cognitive, and emotional/regulatory development during preadolescence and adolescence; 2) determine the effects of timing, dose, and duration of alcohol on brain and cognitive development; 3) assess recovery of neural and behavioral function to determine if the plasticity of the adolescent brain makes it more or less vulnerable to alcohol's acute and chronic effects; 4) understand how other key covariates (e.g., existing or emerging psychopathology, family history of alcoholism, demographics, pubertal development) factor into alcohol's effects on the brain; and 5) identify early neural, cognitive, and affective markers that may predict alcohol abuse and dependence during adolescence and/or adulthood.

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Brain-imaging and Adolescent Neuroscience Consortium
Study Start Date : September 2012
Estimated Primary Completion Date : March 2017
Estimated Study Completion Date : September 2017

Alcohol-naive adolescents
A general population longitudinal cohort of alcohol-naïve (or h/o minimal recent-onset drinking) adolescents in three specific age-groups: early (12-14 y/o), middle (15-17 y/o), and late (18-21 y/o).
Treatment sample
A sample of adolescents who have a >1 year history of heavy drinking but have agreed to stop drinking as part of their treatment plan
High risk sample
High-risk adolescents who have a family history of alcohol-use disorder and other risk factors (symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), Conduct Disorder, or Mood Disorder)

Biospecimen Retention:   Samples With DNA
Saliva DNA samples for future analyses.

Information from the National Library of Medicine

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Ages Eligible for Study:   12 Years to 21 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Male and female adolescents 12-21 years-of-age presenting for care at one of the participating medical clinics

Inclusion Criteria:

  • able to read and understand English
  • available for follow-up
  • parental consent/adolescent assent for those 12-17 years
  • consent for those 18-21 years

Exclusion Criteria:

  • Weight > 300 lbs
  • braces or unremovable embedded metal
  • claustrophobia or inability to lie still in MRI machine
  • current or past 12-mos pregnancy (females)
  • requires urgent medical/mental health care

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01511679

United States, Massachusetts
McLean Hospital
Belmont, Massachusetts, United States, 02478
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Boston University School of Medicine
Boston, Massachusetts, United States, 02118
Massachusetts Institute of Technology
Cambridge, Massachusetts, United States, 02139
Sponsors and Collaborators
Boston Children’s Hospital
Massachusetts General Hospital
Mclean Hospital
Massachusetts Institute of Technology
Principal Investigator: John R Knight, MD Boston Children’s Hospital
Principal Investigator: Gordon J Harris, PhD Massachusetts General Hospital
Principal Investigator: Simon Warfield, PhD Boston Children’s Hospital
Principal Investigator: Avram Holmes, PhD Harvard University
Principal Investigator: Scott Lukas, PhD Mclean Hospital
Principal Investigator: Marisa Silveri, PhD Mclean Hospital
Principal Investigator: Marlene Oscar Berman, PhD Boston University
Principal Investigator: John Gabrieli, PhD Massachusetts Institute of Technology

Additional Information:
Responsible Party: Boston Children’s Hospital Identifier: NCT01511679     History of Changes
Other Study ID Numbers: BANC RFA-AA-12-006
First Posted: January 19, 2012    Key Record Dates
Last Update Posted: January 3, 2013
Last Verified: January 2013

Keywords provided by Boston Children’s Hospital:
Alcohol abuse

Additional relevant MeSH terms:
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Anti-Infective Agents, Local
Anti-Infective Agents
Central Nervous System Depressants
Physiological Effects of Drugs